BACKGROUND & AIMS: The Inhibitory Control Test has been proposed as a tool to detect the persistence of cognitive defects after the resolution of overt hepatic encephalopathy (OHE). We tested learning abilities of cirrhotic patients using the Psychometric Hepatic Encephalopathy Score (PHES). METHODS: One hundred six cirrhotic patients who agreed to be examined twice within 3 days were studied using the PHES. Twenty-seven patients had previous OHE; of the remaining 79 patients, 34 were affected by minimal HE and 45 were normal. RESULTS: Among patients without previous OHE, PHESs significantly improved at the second examination; this learning effect was present in the patients with or without minimal HE. To the contrary, learning ability was lost in patients with previous OHE. Even among the 8 patients with history of HE and normal PHESs in the first examination, repeated testing showed a lack of learning capacity. CONCLUSIONS: HE is not a fully reversible condition. Residual cognitive impairments should be evaluated by specific tests, based on patients' learning capacities.

Evidence of Persistent Cognitive Impairment After Resolution of Overt Hepatic Encephalopathy / Riggio, Oliviero; Ridola, Lorenzo; Pasquale, Chiara; Nardelli, Silvia; Pentassuglio, Ilaria; Moscucci, Federica; Merli, Manuela. - In: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. - ISSN 1542-3565. - STAMPA. - 9:2(2011), pp. 181-183. [10.1016/j.cgh.2010.10.002]

Evidence of Persistent Cognitive Impairment After Resolution of Overt Hepatic Encephalopathy

RIGGIO, Oliviero;RIDOLA, LORENZO;PASQUALE, CHIARA;NARDELLI, SILVIA;PENTASSUGLIO, ILARIA;MOSCUCCI , FEDERICA;MERLI, Manuela
2011

Abstract

BACKGROUND & AIMS: The Inhibitory Control Test has been proposed as a tool to detect the persistence of cognitive defects after the resolution of overt hepatic encephalopathy (OHE). We tested learning abilities of cirrhotic patients using the Psychometric Hepatic Encephalopathy Score (PHES). METHODS: One hundred six cirrhotic patients who agreed to be examined twice within 3 days were studied using the PHES. Twenty-seven patients had previous OHE; of the remaining 79 patients, 34 were affected by minimal HE and 45 were normal. RESULTS: Among patients without previous OHE, PHESs significantly improved at the second examination; this learning effect was present in the patients with or without minimal HE. To the contrary, learning ability was lost in patients with previous OHE. Even among the 8 patients with history of HE and normal PHESs in the first examination, repeated testing showed a lack of learning capacity. CONCLUSIONS: HE is not a fully reversible condition. Residual cognitive impairments should be evaluated by specific tests, based on patients' learning capacities.
psychometric evaluation; hepatic encephalopathy; liver cirrhosis; mild cognitive impairment
01 Pubblicazione su rivista::01a Articolo in rivista
Evidence of Persistent Cognitive Impairment After Resolution of Overt Hepatic Encephalopathy / Riggio, Oliviero; Ridola, Lorenzo; Pasquale, Chiara; Nardelli, Silvia; Pentassuglio, Ilaria; Moscucci, Federica; Merli, Manuela. - In: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. - ISSN 1542-3565. - STAMPA. - 9:2(2011), pp. 181-183. [10.1016/j.cgh.2010.10.002]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/81660
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