Natural killer cells (NKs) are important effectors of the innate immune system, with marked antitumor activity. Imaging NK trafficking in vivo may be relevant to following up the efficacy of new therapeutic approaches aiming at increasing tumor-infiltrating NKs (TINKs). The specific aims of present study were to efficiently target NKs using a (99m)Tc-anti-CD56 and to image human NK trafficking in SCID mice bearing human cancer.
In Vivo Imaging of Natural Killer Cell Trafficking in Tumors / Galli, Filippo; Rapisarda, Anna Serafina; Stabile, MARIA HELENA; Malviya, Gaurav; Manni, Isabella; Bonanno, Elena; Piaggio, Giulia; Gismondi, Angela; Santoni, Angela; Signore, Alberto. - In: THE JOURNAL OF NUCLEAR MEDICINE. - ISSN 0161-5505. - STAMPA. - 56:10(2015), pp. 1575-80-1580. [10.2967/jnumed.114.152918]
In Vivo Imaging of Natural Killer Cell Trafficking in Tumors
GALLI, FILIPPO;STABILE, MARIA HELENA;GISMONDI, Angela;SANTONI, Angela;SIGNORE, Alberto
2015
Abstract
Natural killer cells (NKs) are important effectors of the innate immune system, with marked antitumor activity. Imaging NK trafficking in vivo may be relevant to following up the efficacy of new therapeutic approaches aiming at increasing tumor-infiltrating NKs (TINKs). The specific aims of present study were to efficiently target NKs using a (99m)Tc-anti-CD56 and to image human NK trafficking in SCID mice bearing human cancer.| File | Dimensione | Formato | |
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