Growing evidence is showing a role of neurogenic inflammation in allergic reactions, with sensory and autonomic nerve fibers releasing neuromediators, which may actively participate in the allergic inflammatory cascade. Although the cornea is the most densely innervated tissue of the human body, little is known on the role of neuromediators at the ocular surface. In this study, we aimed at evaluating the role of substance P (SP), calcitonine gene related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in allergic reactions of the ocular surface.

Tear levels of neuropeptides increase after specific allergen challenge in allergic conjunctivitis / Sacchetti, Marta; Micera, Alessandra; Lambiase, Alessandro; Speranza, Stefania; Mantelli, Flavio; Petrachi, Girolamo; Bonini, Sergio; Bonini, Stefano. - In: MOLECULAR VISION. - ISSN 1090-0535. - STAMPA. - 17:(2011), pp. 47-52.

Tear levels of neuropeptides increase after specific allergen challenge in allergic conjunctivitis

SACCHETTI, MARTA;LAMBIASE, ALESSANDRO;
2011

Abstract

Growing evidence is showing a role of neurogenic inflammation in allergic reactions, with sensory and autonomic nerve fibers releasing neuromediators, which may actively participate in the allergic inflammatory cascade. Although the cornea is the most densely innervated tissue of the human body, little is known on the role of neuromediators at the ocular surface. In this study, we aimed at evaluating the role of substance P (SP), calcitonine gene related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in allergic reactions of the ocular surface.
2011
Adult; Allergens; Animals; Bronchial Provocation Tests; Calcitonin Gene-Related Peptide; Conjunctivitis, Allergic; Enzyme-Linked Immunosorbent Assay; Eye; Female; Humans; Inflammation; Male; Neuropeptide Y; Neuropeptides; Pyroglyphidae; Tears; Vasoactive Intestinal Peptide
01 Pubblicazione su rivista::01a Articolo in rivista
Tear levels of neuropeptides increase after specific allergen challenge in allergic conjunctivitis / Sacchetti, Marta; Micera, Alessandra; Lambiase, Alessandro; Speranza, Stefania; Mantelli, Flavio; Petrachi, Girolamo; Bonini, Sergio; Bonini, Stefano. - In: MOLECULAR VISION. - ISSN 1090-0535. - STAMPA. - 17:(2011), pp. 47-52.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/807418
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