The goal of this study was to evaluate the presence of extrahepatic damage and the uniformity and reversibility of the histological findings in CCl4-induced liver cirrhosis in the rat. To verify these findings rats were sacrificed 2 and 10 weeks after a treatment consisting of ten intragastric doses of CCl4, administered weekly. All treated rats developed an irreversible micronodular cirrhosis with no damage to the brain, kidney and pancreas. Moreover, rats sacrificed 2 weeks after the last CCl4 dose showed a number of functional alterations usually observed in man. In particular, low branched chain/aromatic amino acids (BCAA/AAA) plasma ratio, high ammonia, low zinc and high insulin with normal blood glucose were obtained.
CARBON TETRACHLORIDE-INDUCED EXPERIMENTAL CIRRHOSIS IN THE RAT - A REAPPRAISAL OF THE MODEL / F., Ariosto; Riggio, Oliviero; A., Cantafora; S., Colucci; Gaudio, Eugenio; C., Mechelli; Merli, Manuela; S., Seri; L., Capocaccia. - In: EUROPEAN SURGICAL RESEARCH. - ISSN 0014-312X. - 21:5(1989), pp. 280-286. [10.1159/000129038]
CARBON TETRACHLORIDE-INDUCED EXPERIMENTAL CIRRHOSIS IN THE RAT - A REAPPRAISAL OF THE MODEL
RIGGIO, Oliviero;GAUDIO, EUGENIO;MERLI, Manuela;
1989
Abstract
The goal of this study was to evaluate the presence of extrahepatic damage and the uniformity and reversibility of the histological findings in CCl4-induced liver cirrhosis in the rat. To verify these findings rats were sacrificed 2 and 10 weeks after a treatment consisting of ten intragastric doses of CCl4, administered weekly. All treated rats developed an irreversible micronodular cirrhosis with no damage to the brain, kidney and pancreas. Moreover, rats sacrificed 2 weeks after the last CCl4 dose showed a number of functional alterations usually observed in man. In particular, low branched chain/aromatic amino acids (BCAA/AAA) plasma ratio, high ammonia, low zinc and high insulin with normal blood glucose were obtained.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.