In the last decade, ample evidence has demonstrated the growing importance of androgen receptor (AR) CAG repeat polymorphism in andrology. This genetic parameter is able to condition the peripheral effects of testosterone and therefore to influence male sexual function and fertility, cardiovascular risk, body composition, bone metabolism, the risk of prostate and testicular cancer, the psychiatric status, and the onset of neurodegenerative disorders. In this review, we extensively discuss the literature data and identify a role for AR CAG repeat polymorphism in conditioning the systemic testosterone effects. In particular, our main purpose was to provide an updated text able to shed light on the many and often contradictory findings reporting an influence of CAG repeat polymorphism on the targets of testosterone action. © 2015 Giacomo Tirabassi et al.

Influence of CAG repeat polymorphism on the targets of testosterone action / Tirabassi, G; Cignarelli, A; Perrini, S; Delli Muti, N; Furlani, G; Gallo, Mariagrazia; Pallotti, Francesco; Paoli, Donatella; Giorgino, F; Lombardo, Francesco; Gandini, Loredana; Lenzi, Andrea; Balercia, G.. - In: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY. - ISSN 1687-8345. - ELETTRONICO. - 2015:(2015). [10.1155/2015/298107]

Influence of CAG repeat polymorphism on the targets of testosterone action

GALLO, MARIAGRAZIA;PALLOTTI, FRANCESCO;PAOLI, Donatella;LOMBARDO, Francesco;GANDINI, Loredana;LENZI, Andrea;
2015

Abstract

In the last decade, ample evidence has demonstrated the growing importance of androgen receptor (AR) CAG repeat polymorphism in andrology. This genetic parameter is able to condition the peripheral effects of testosterone and therefore to influence male sexual function and fertility, cardiovascular risk, body composition, bone metabolism, the risk of prostate and testicular cancer, the psychiatric status, and the onset of neurodegenerative disorders. In this review, we extensively discuss the literature data and identify a role for AR CAG repeat polymorphism in conditioning the systemic testosterone effects. In particular, our main purpose was to provide an updated text able to shed light on the many and often contradictory findings reporting an influence of CAG repeat polymorphism on the targets of testosterone action. © 2015 Giacomo Tirabassi et al.
2015
androgen receptor; testosterone, AR gene; azoospermia; binding affinity; body composition; bone density; bone metabolism; CAG repeat; cancer risk; cardiovascular risk; degenerative disease; depression; disease severity; DNA polymorphism; erectile dysfunction; gene; gene frequency; gene function; haplotype; hormone action; hormone substitution; human; male infertility; oligospermia; priority journal; prostate disease; protein binding; protein interaction; Review; risk assessment; risk factor; sexual function; testis cancer; testosterone blood level
01 Pubblicazione su rivista::01a Articolo in rivista
Influence of CAG repeat polymorphism on the targets of testosterone action / Tirabassi, G; Cignarelli, A; Perrini, S; Delli Muti, N; Furlani, G; Gallo, Mariagrazia; Pallotti, Francesco; Paoli, Donatella; Giorgino, F; Lombardo, Francesco; Gandini, Loredana; Lenzi, Andrea; Balercia, G.. - In: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY. - ISSN 1687-8345. - ELETTRONICO. - 2015:(2015). [10.1155/2015/298107]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/799702
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