Accumulation of triglyceride-containing lipid droplets (LDs) within hepatocytes in NAFLD patients is a potentially reversible process, although sustained activation of inflammatory signaling pathways leads to non-alcoholic steatohepatitis (NASH) that can evolve into cirrhosis and HCC. Here we investigated the role of a new EZH2-phosphoSTAT3-miRNAs pathway in LD accumulation and intracellular inflammation in an in vitro cellular model of vescicularsteatosis
METFORMIN TARGETS A NEW EZH2-PHOSPHOSTAT3-MIRNAS PATHWAY TO INHIBIT LIPID DROPLETS ACCUMULATION AND INTRACELLULAR INFLAMMATION / Pediconi, Natalia; 2, ; DI COCCO, Silvia; Salerno, Debora; Belloni, Laura; 3, ; Piconese, Silvia; Barnaba, Vincenzo; Levrero, Massimo; 3,. - ELETTRONICO. - ISSN: 1590-8658:(2015).
METFORMIN TARGETS A NEW EZH2-PHOSPHOSTAT3-MIRNAS PATHWAY TO INHIBIT LIPID DROPLETS ACCUMULATION AND INTRACELLULAR INFLAMMATION
PEDICONI, NATALIA;DI COCCO, SILVIA;SALERNO, DEBORA;BELLONI, Laura;PICONESE, SILVIA;BARNABA, Vincenzo;LEVRERO, Massimo;
2015
Abstract
Accumulation of triglyceride-containing lipid droplets (LDs) within hepatocytes in NAFLD patients is a potentially reversible process, although sustained activation of inflammatory signaling pathways leads to non-alcoholic steatohepatitis (NASH) that can evolve into cirrhosis and HCC. Here we investigated the role of a new EZH2-phosphoSTAT3-miRNAs pathway in LD accumulation and intracellular inflammation in an in vitro cellular model of vescicularsteatosisI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
