Currently, the use of oral and systemic bisphosphonates, in the form of anti-osteoporosis medications or as a part of a chemotherapeutic regimen for several malignant diseases, is increasing dramatically in a large group of orthodontic patients. Animal studies have reported adverse dental effects from bisphosphonates, including decreased tooth movement, impaired bone healing, and osteonecrosis in the mandible and the maxilla.
Effects of bisphosphonates in orthodontic therapy:systematic review / Rodolfino, D; Saccucci, Matteo; Filippakos, A; Gerxhani, R; Lopez, G; Felice, F; D. ' Arcangelo, C.. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - ELETTRONICO. - 26:2 Suppl(2012), pp. 29-33-29-33.