The increase of nerve growth factor (NGF) plasma levels in vernal keratoconjunctivitis (VKC) patients has been demonstrated previously. Results of numerous studies in vitro and in vivo have shown that NGF modulates the synthesis of substance P (SP), a neuropeptide involved in the pathogenesis of human allergic diseases. In this study the involvement of SP in this allergic conjunctivitis is investigated, along with its relationship with NGF and other systemic and local markers of VKC.

Increased plasma levels of substance P in vernal keratoconjunctivitis / Lambiase, Alessandro; Bonini, S; Micera, A; Tirassa, P; Magrini, L; Bonini, S; Aloe, L.. - In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. - ISSN 0146-0404. - STAMPA. - 38:10(1997), pp. 2161-2164.

Increased plasma levels of substance P in vernal keratoconjunctivitis

LAMBIASE, ALESSANDRO;
1997

Abstract

The increase of nerve growth factor (NGF) plasma levels in vernal keratoconjunctivitis (VKC) patients has been demonstrated previously. Results of numerous studies in vitro and in vivo have shown that NGF modulates the synthesis of substance P (SP), a neuropeptide involved in the pathogenesis of human allergic diseases. In this study the involvement of SP in this allergic conjunctivitis is investigated, along with its relationship with NGF and other systemic and local markers of VKC.
1997
Adolescent; Adult; Blood Proteins; Child; Child, Preschool; Conjunctivitis, Allergic; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Immunoglobulin E; Inflammation Mediators; Lymphocytes; Male; Mast Cells; Nerve Growth Factors; Radioimmunoassay; Substance P; Ribonucleases
01 Pubblicazione su rivista::01a Articolo in rivista
Increased plasma levels of substance P in vernal keratoconjunctivitis / Lambiase, Alessandro; Bonini, S; Micera, A; Tirassa, P; Magrini, L; Bonini, S; Aloe, L.. - In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. - ISSN 0146-0404. - STAMPA. - 38:10(1997), pp. 2161-2164.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/793310
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