To evaluate the role of nerve growth factor (NGF) in remodeling processes of vernal keratoconjunctivitis (VKC). VKC is a chronic inflammatory disorder of the conjunctiva and is characterized by marked tissue remodeling. NGF, a pleiotrophic factor with documented profibrogenic activities, is produced by inflammatory and structural cells populating the VKC conjunctiva and is increased in the serum and tears of VKC patients.

Nerve growth factor has a modulatory role on human primary fibroblast cultures derived from vernal keratoconjunctivitis-affected conjunctiva / Micera, Alessandra; Lambiase, Alessandro; Stampachiacchiere, Barbara; Sgrulletta, Roberto; Normando, Eduardo Maria; Bonini, Sergio; Bonini, Stefano. - In: MOLECULAR VISION. - ISSN 1090-0535. - STAMPA. - 13:(2007), pp. 981-987.

Nerve growth factor has a modulatory role on human primary fibroblast cultures derived from vernal keratoconjunctivitis-affected conjunctiva

LAMBIASE, ALESSANDRO;
2007

Abstract

To evaluate the role of nerve growth factor (NGF) in remodeling processes of vernal keratoconjunctivitis (VKC). VKC is a chronic inflammatory disorder of the conjunctiva and is characterized by marked tissue remodeling. NGF, a pleiotrophic factor with documented profibrogenic activities, is produced by inflammatory and structural cells populating the VKC conjunctiva and is increased in the serum and tears of VKC patients.
2007
Actins; Adolescent; Animals; Cells, Cultured; Child; Collagen Type I; Collagen Type IV; Conjunctiva; Conjunctivitis, Allergic; Down-Regulation; Fibroblasts; Humans; Male; Matrix Metalloproteinase 9; Mice; Muscle, Smooth; Nerve Growth Factor; RNA, Messenger; Receptor, Nerve Growth Factor; Receptor, trkA; Up-Regulation
01 Pubblicazione su rivista::01a Articolo in rivista
Nerve growth factor has a modulatory role on human primary fibroblast cultures derived from vernal keratoconjunctivitis-affected conjunctiva / Micera, Alessandra; Lambiase, Alessandro; Stampachiacchiere, Barbara; Sgrulletta, Roberto; Normando, Eduardo Maria; Bonini, Sergio; Bonini, Stefano. - In: MOLECULAR VISION. - ISSN 1090-0535. - STAMPA. - 13:(2007), pp. 981-987.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/793213
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