Erythrocytes are peculiar cells aimed at the delivery of oxygen and nitric oxide to the periphery and carbon dioxide to the lungs. In addition, they also exert, under physiological conditions, a scavenging activity towards reactive oxygen and nitrogen species often over-produced in morbidity states, e.g. in inflamed tissues. Their deformability is essential for their circulation, specifically in small blood vessels, and this is an important pre-requisite for such vascular "antioxidant" functions. On the other hand, if the erythrocyte undergoes changes in its redox status, i.e. is not capable of counteracting the pro-oxidant status of the microenvironment, it becomes a source of reactive species and, consequently, its typical structural and functional features are lost. More importantly, the oxidatively modified red cell increases its aggregability and adhesiveness to the endothelium and to other blood cells, thus contributing to vascular damage. In line with recent data from the literature, erythrocytes can be proposed as bioindicators of progression in chronic or acute diseases characterized, as a hallmark, by oxidative alterations. (c) 2007 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

The microenvironment can shift erythrocytes from a friendly to a harmful behavior: Pathogenetic implications for vascular diseases / M., Minetti; Agati, Luciano; W., Malorni. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - STAMPA. - 75:1(2007), pp. 21-28. [10.1016/j.cardiores.2007.03.007]

The microenvironment can shift erythrocytes from a friendly to a harmful behavior: Pathogenetic implications for vascular diseases

AGATI, Luciano;
2007

Abstract

Erythrocytes are peculiar cells aimed at the delivery of oxygen and nitric oxide to the periphery and carbon dioxide to the lungs. In addition, they also exert, under physiological conditions, a scavenging activity towards reactive oxygen and nitrogen species often over-produced in morbidity states, e.g. in inflamed tissues. Their deformability is essential for their circulation, specifically in small blood vessels, and this is an important pre-requisite for such vascular "antioxidant" functions. On the other hand, if the erythrocyte undergoes changes in its redox status, i.e. is not capable of counteracting the pro-oxidant status of the microenvironment, it becomes a source of reactive species and, consequently, its typical structural and functional features are lost. More importantly, the oxidatively modified red cell increases its aggregability and adhesiveness to the endothelium and to other blood cells, thus contributing to vascular damage. In line with recent data from the literature, erythrocytes can be proposed as bioindicators of progression in chronic or acute diseases characterized, as a hallmark, by oxidative alterations. (c) 2007 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
2007
biomarkers; erythrocyte; redox; vascular complications; vascular diseases
01 Pubblicazione su rivista::01a Articolo in rivista
The microenvironment can shift erythrocytes from a friendly to a harmful behavior: Pathogenetic implications for vascular diseases / M., Minetti; Agati, Luciano; W., Malorni. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - STAMPA. - 75:1(2007), pp. 21-28. [10.1016/j.cardiores.2007.03.007]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/79206
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