Phasic alertness represents the ability to increase response readiness to a target following an external warning stimulus. Specific networks in the frontal and parietal regions appear to be involved in the alert state. In this study, we examined the role of the right dorsolateral prefrontal cortex (DLPFC) during the attentional processing of a stimulus using a cued double-choice reaction time task. The evaluation of these processes was conducted by means of Event-Related Potentials (ERPs), in particular by using the Contingent Negative Variation (CNV), and repetitive 1-Hz Transcranial Magnetic Stimulation (rTMS). Transient virtual inhibition of the right DLPFC induced by real 1-Hz rTMS stimulation led to a significant decrease in total CNV and W1-CNV areas if compared with the basal and post-sham rTMS conditions. Reaction times (RTs) did not decrease after inhibitory rTMS, but they did improve after sham stimulation. These results suggest that the right DLPFC plays a crucial role in the genesis and maintenance of the alerting state and learning processes.

The role of the right dorsolateral prefrontal cortex in phasic alertness: evidence from a contingent negative variation and repetitive transcranial magnetic stimulation study / Mannarelli, Daniela; Pauletti, Caterina; Grippo, Antonello; Amantini, Aldo; Augugliaro, Vito; Curra', Antonio; Missori, Paolo; Locuratolo, Nicoletta; DE LUCIA, MARIA CATERINA; Rinalduzzi, Steno; Fattapposta, Francesco. - In: NEURAL PLASTICITY. - ISSN 2090-5904. - ELETTRONICO. - Volume 2015 (2015):Article ID 410785(2015). [10.1155/2015/410785]

The role of the right dorsolateral prefrontal cortex in phasic alertness: evidence from a contingent negative variation and repetitive transcranial magnetic stimulation study

MANNARELLI, DANIELA;PAULETTI, CATERINA;CURRA', antonio;MISSORI, Paolo;LOCURATOLO, NICOLETTA;DE LUCIA, MARIA CATERINA;FATTAPPOSTA, FRANCESCO
2015

Abstract

Phasic alertness represents the ability to increase response readiness to a target following an external warning stimulus. Specific networks in the frontal and parietal regions appear to be involved in the alert state. In this study, we examined the role of the right dorsolateral prefrontal cortex (DLPFC) during the attentional processing of a stimulus using a cued double-choice reaction time task. The evaluation of these processes was conducted by means of Event-Related Potentials (ERPs), in particular by using the Contingent Negative Variation (CNV), and repetitive 1-Hz Transcranial Magnetic Stimulation (rTMS). Transient virtual inhibition of the right DLPFC induced by real 1-Hz rTMS stimulation led to a significant decrease in total CNV and W1-CNV areas if compared with the basal and post-sham rTMS conditions. Reaction times (RTs) did not decrease after inhibitory rTMS, but they did improve after sham stimulation. These results suggest that the right DLPFC plays a crucial role in the genesis and maintenance of the alerting state and learning processes.
2015
neurology; neurology (clinical)
01 Pubblicazione su rivista::01a Articolo in rivista
The role of the right dorsolateral prefrontal cortex in phasic alertness: evidence from a contingent negative variation and repetitive transcranial magnetic stimulation study / Mannarelli, Daniela; Pauletti, Caterina; Grippo, Antonello; Amantini, Aldo; Augugliaro, Vito; Curra', Antonio; Missori, Paolo; Locuratolo, Nicoletta; DE LUCIA, MARIA CATERINA; Rinalduzzi, Steno; Fattapposta, Francesco. - In: NEURAL PLASTICITY. - ISSN 2090-5904. - ELETTRONICO. - Volume 2015 (2015):Article ID 410785(2015). [10.1155/2015/410785]
File allegati a questo prodotto
File Dimensione Formato  
Mannarelli_right-dorsolateral-prefrontal_2015.pdf

accesso aperto

Note: Articolo principale
Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.62 MB
Formato Adobe PDF
1.62 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/791344
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 19
social impact