Endothelial dysfunction (ED) plays a role in diabetic cardiovascular complications. Hyperglycemia increases cytockines involved in vascular inflammation. Inhibition of phosphodiesterase type 5 (PDE5) exerts a relaxation on corpora cavernosa and has cardioprotective properties. The effect of chronic sildenafil treatment, on ED markers and metabolic parameters in a non-randomized study on men with type 2 diabetes (T2DM), was investigated.
Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes / Mandosi, Elisabetta; Giannetta, Elisa; Filardi, Tiziana; Lococo, Manuela; Bertolini, Camilla; Fallarino, Mara; Gianfrilli, Daniele; Venneri, MARY ANNA; Lenti, Luisa; Lenzi, Andrea; Morano, Susanna. - In: EXPERT OPINION ON THERAPEUTIC TARGETS. - ISSN 1472-8222. - STAMPA. - (2015), pp. 1-6. [10.1517/14728222.2015.1066337]
Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes
MANDOSI, ELISABETTA;GIANNETTA, ELISA;FILARDI, TIZIANA;FALLARINO, Mara;GIANFRILLI, DANIELE;VENNERI, MARY ANNA;LENTI, Luisa;LENZI, Andrea;MORANO, Susanna
2015
Abstract
Endothelial dysfunction (ED) plays a role in diabetic cardiovascular complications. Hyperglycemia increases cytockines involved in vascular inflammation. Inhibition of phosphodiesterase type 5 (PDE5) exerts a relaxation on corpora cavernosa and has cardioprotective properties. The effect of chronic sildenafil treatment, on ED markers and metabolic parameters in a non-randomized study on men with type 2 diabetes (T2DM), was investigated.| File | Dimensione | Formato | |
|---|---|---|---|
|
Mandosi_Endothelial-dysfunction_2015.pdf
accesso aperto
Note: Manoscritto pubblicato
Tipologia:
Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
251.37 kB
Formato
Adobe PDF
|
251.37 kB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
