Endothelial dysfunction (ED) plays a role in diabetic cardiovascular complications. Hyperglycemia increases cytockines involved in vascular inflammation. Inhibition of phosphodiesterase type 5 (PDE5) exerts a relaxation on corpora cavernosa and has cardioprotective properties. The effect of chronic sildenafil treatment, on ED markers and metabolic parameters in a non-randomized study on men with type 2 diabetes (T2DM), was investigated.

Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes / Mandosi, Elisabetta; Giannetta, Elisa; Filardi, Tiziana; Lococo, Manuela; Bertolini, Camilla; Fallarino, Mara; Gianfrilli, Daniele; Venneri, MARY ANNA; Lenti, Luisa; Lenzi, Andrea; Morano, Susanna. - In: EXPERT OPINION ON THERAPEUTIC TARGETS. - ISSN 1472-8222. - STAMPA. - (2015), pp. 1-6. [10.1517/14728222.2015.1066337]

Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes

MANDOSI, ELISABETTA;GIANNETTA, ELISA;FILARDI, TIZIANA;FALLARINO, Mara;GIANFRILLI, DANIELE;VENNERI, MARY ANNA;LENTI, Luisa;LENZI, Andrea;MORANO, Susanna
2015

Abstract

Endothelial dysfunction (ED) plays a role in diabetic cardiovascular complications. Hyperglycemia increases cytockines involved in vascular inflammation. Inhibition of phosphodiesterase type 5 (PDE5) exerts a relaxation on corpora cavernosa and has cardioprotective properties. The effect of chronic sildenafil treatment, on ED markers and metabolic parameters in a non-randomized study on men with type 2 diabetes (T2DM), was investigated.
2015
P-selectin; phosphodiesterase type-5 inhibitors; sildenafil; type 2 diabetes
01 Pubblicazione su rivista::01a Articolo in rivista
Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes / Mandosi, Elisabetta; Giannetta, Elisa; Filardi, Tiziana; Lococo, Manuela; Bertolini, Camilla; Fallarino, Mara; Gianfrilli, Daniele; Venneri, MARY ANNA; Lenti, Luisa; Lenzi, Andrea; Morano, Susanna. - In: EXPERT OPINION ON THERAPEUTIC TARGETS. - ISSN 1472-8222. - STAMPA. - (2015), pp. 1-6. [10.1517/14728222.2015.1066337]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/789982
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