Sirtuins (SIRTs), ubiquitous deacetylases, are main regulators of energy homeostasis and metabolism. SIRT1 has a positive impact on obesity, diabetes mellitus, liver steatosis, and other metabolic disorders. Lean subjects have higher expression of SIRT1 in the adipose tissue compared to obese. However, it is not known whether weight loss associates with changes in blood SIRT1. We evaluated the effect of weight loss on circulating SIRT1, metabolic parameters, and body composition.
Circulating SIRT1 increases after intragastric balloon fat loss in obese patients / Mariani, Stefania; Fiore, Daniela; Persichetti, Agnese; Basciani, Sabrina; Lubrano, Carla; Poggiogalle, Eleonora; Genco, Alfredo; Donini, Lorenzo Maria; Gnessi, Lucio. - In: OBESITY SURGERY. - ISSN 0960-8923. - 26:6(2016), pp. 1215-1220. [10.1007/s11695-015-1859-4]
Circulating SIRT1 increases after intragastric balloon fat loss in obese patients
MARIANI, Stefania;FIORE, DANIELA;PERSICHETTI, AGNESE;BASCIANI, Sabrina;LUBRANO, Carla;POGGIOGALLE, ELEONORA;GENCO, Alfredo;DONINI, Lorenzo Maria;GNESSI, Lucio
2016
Abstract
Sirtuins (SIRTs), ubiquitous deacetylases, are main regulators of energy homeostasis and metabolism. SIRT1 has a positive impact on obesity, diabetes mellitus, liver steatosis, and other metabolic disorders. Lean subjects have higher expression of SIRT1 in the adipose tissue compared to obese. However, it is not known whether weight loss associates with changes in blood SIRT1. We evaluated the effect of weight loss on circulating SIRT1, metabolic parameters, and body composition.| File | Dimensione | Formato | |
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