The paper describes the analysis of nine sulfonamides, chosen as the most widely used representatives of an important class of antibacterial drugs. Atomic emission detection has been found to allow simultaneous quantification and identification of the N1-methylated derivatives, which are resolved efficiently by conventional capillary gas chromatography. Results are given concerning the linearity of the response and the characterization of the individual compounds by the elemental ratio of their carbon, nitrogen and sulfur content. The method looks promising for the quantitative analysis and confirmation of sulfonamide residues in complex mixtures.
Determination of sulfonamide antibiotics by gas chromatography coupled with atomic emission detection / Chiavarino, Barbara; Crestoni, Maria Elisa; DI MARZIO, Annito; Fornarini, Simonetta. - In: JOURNAL OF CHROMATOGRAPHY B. BIOMEDICAL SCIENCES AND APPLICATIONS. - ISSN 1387-2273. - STAMPA. - 706:2(1998), pp. 269-277. [10.1016/s0378-4347(97)00568-9]
Determination of sulfonamide antibiotics by gas chromatography coupled with atomic emission detection
CHIAVARINO, Barbara;CRESTONI, Maria Elisa;DI MARZIO, Annito;FORNARINI, Simonetta
1998
Abstract
The paper describes the analysis of nine sulfonamides, chosen as the most widely used representatives of an important class of antibacterial drugs. Atomic emission detection has been found to allow simultaneous quantification and identification of the N1-methylated derivatives, which are resolved efficiently by conventional capillary gas chromatography. Results are given concerning the linearity of the response and the characterization of the individual compounds by the elemental ratio of their carbon, nitrogen and sulfur content. The method looks promising for the quantitative analysis and confirmation of sulfonamide residues in complex mixtures.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
