Background Bloodstream infections (BSIs) from multidrug-resistant (MDR) bacteria cause morbidity and mortality in intensive care unit (ICU) patients worldwide. This study investigated the incidence of BSIs in 5 adult general ICUs in Rome, Italy, and evaluated the mortality rate and risk factors associated with these infections. Methods Over a 12-month period, 1,318 patients were enrolled. Demographic characteristics, Simplified Acute Physiology Score II (SAPS II), comorbidities, and BSI isolate data were collected. After stratification for the outcome, statistical analysis was performed to assess the impact of patient risk factors on in-hospital mortality. Results There were 324 BSIs in 175 patients recorded, with an in-hospital mortality rate of 46%. Univariate analysis revealed that SAPS II, cardiac comorbidity, and Klebsiella pneumoniae BSI were significantly associated with a higher risk of death. Having a K pneumoniae BSI and cardiac illness at admission were both confirmed to be associated with death by multivariate analysis (P =.0162 and P =.0158, respectively). Most of the K pneumoniae isolates showed high resistance rates to carbapenems. Conclusion BSIs caused by K pneumoniae and cardiovascular comorbidity in ICU patients are associated with a higher risk of death. Thorough surveillance for MDR pathogens and stratification of the patients' risk on admission into the ICU are key to improving the outcomes of these infections.

Microbiologic characteristics and predictors of mortality in bloodstream infections in intensive care unit patients. a 1-year, large, prospective surveillance study in 5 Italian hospitals / Delle Rose, Diego; Sordillo, Pasquale; Gini, Sabina; Cerva, Carlotta; Boros, Stefano; Rezza, Giovanni; Meledandri, Marcello; Gallo, Maria Teresa; Prignano, Grazia; Caccese, Roberta; D’Ambrosio, Mario; Citterio, Giorgia; Rocco, Monica; De Leonardis, Francesco; Natoli, Silvia; Fontana, Carla; Favaro, Marco; Celeste, Maria Grazia; Franci, Tiziana; Testore, Gian Piero; Andreoni, Massimo; Sarmati, Loredana. - In: AMERICAN JOURNAL OF INFECTION CONTROL. - ISSN 0196-6553. - STAMPA. - 43:11(2015), pp. 1178-1183. [10.1016/j.ajic.2015.06.023]

Microbiologic characteristics and predictors of mortality in bloodstream infections in intensive care unit patients. a 1-year, large, prospective surveillance study in 5 Italian hospitals

CERVA, CARLOTTA;CITTERIO, GIORGIA;ROCCO, Monica;
2015

Abstract

Background Bloodstream infections (BSIs) from multidrug-resistant (MDR) bacteria cause morbidity and mortality in intensive care unit (ICU) patients worldwide. This study investigated the incidence of BSIs in 5 adult general ICUs in Rome, Italy, and evaluated the mortality rate and risk factors associated with these infections. Methods Over a 12-month period, 1,318 patients were enrolled. Demographic characteristics, Simplified Acute Physiology Score II (SAPS II), comorbidities, and BSI isolate data were collected. After stratification for the outcome, statistical analysis was performed to assess the impact of patient risk factors on in-hospital mortality. Results There were 324 BSIs in 175 patients recorded, with an in-hospital mortality rate of 46%. Univariate analysis revealed that SAPS II, cardiac comorbidity, and Klebsiella pneumoniae BSI were significantly associated with a higher risk of death. Having a K pneumoniae BSI and cardiac illness at admission were both confirmed to be associated with death by multivariate analysis (P =.0162 and P =.0158, respectively). Most of the K pneumoniae isolates showed high resistance rates to carbapenems. Conclusion BSIs caused by K pneumoniae and cardiovascular comorbidity in ICU patients are associated with a higher risk of death. Thorough surveillance for MDR pathogens and stratification of the patients' risk on admission into the ICU are key to improving the outcomes of these infections.
2015
bloodstream infections; intensive care unit; klebsiella pneumoniae; microbiology; mortality; predictors; infectious diseases; public health, environmental and occupational health; epidemiology; health policy
01 Pubblicazione su rivista::01a Articolo in rivista
Microbiologic characteristics and predictors of mortality in bloodstream infections in intensive care unit patients. a 1-year, large, prospective surveillance study in 5 Italian hospitals / Delle Rose, Diego; Sordillo, Pasquale; Gini, Sabina; Cerva, Carlotta; Boros, Stefano; Rezza, Giovanni; Meledandri, Marcello; Gallo, Maria Teresa; Prignano, Grazia; Caccese, Roberta; D’Ambrosio, Mario; Citterio, Giorgia; Rocco, Monica; De Leonardis, Francesco; Natoli, Silvia; Fontana, Carla; Favaro, Marco; Celeste, Maria Grazia; Franci, Tiziana; Testore, Gian Piero; Andreoni, Massimo; Sarmati, Loredana. - In: AMERICAN JOURNAL OF INFECTION CONTROL. - ISSN 0196-6553. - STAMPA. - 43:11(2015), pp. 1178-1183. [10.1016/j.ajic.2015.06.023]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/789139
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