The studies on the interplay between β-herpesviruses (CMV, human herpes viruses 6 and 7) and fungi in immunocompromised hosts, have demonstrated that a detailed knowledge of the interaction between the host and the above infectious agents may have a significant clinical relevance. β-herpesviruses may directly be associated to different pathological conditions and may indirectly be involved in the development of opportunistic infections (e.g., fungal infections), allograft rejection and decreased patient survival. Recent in vitro and in vivo studies have pointed out the importance of the microbiome, exposure to microbes and the innate immune system in determining the risk of developing infections; such microbial interactions may modulate the expression of the infection, change the microbial pathogenicity, or increase the immunosuppression.

Interplay between β herpesviruses and fungal infections in transplant patients: from the bench to the bedside / Gentile, Giuseppe; Antonelli, Guido. - In: FUTURE VIROLOGY. - ISSN 1746-0794. - STAMPA. - 10:4(2015), pp. 399-414. [10.2217/fvl.15.4]

Interplay between β herpesviruses and fungal infections in transplant patients: from the bench to the bedside

Gentile, Giuseppe
;
ANTONELLI, Guido
2015

Abstract

The studies on the interplay between β-herpesviruses (CMV, human herpes viruses 6 and 7) and fungi in immunocompromised hosts, have demonstrated that a detailed knowledge of the interaction between the host and the above infectious agents may have a significant clinical relevance. β-herpesviruses may directly be associated to different pathological conditions and may indirectly be involved in the development of opportunistic infections (e.g., fungal infections), allograft rejection and decreased patient survival. Recent in vitro and in vivo studies have pointed out the importance of the microbiome, exposure to microbes and the innate immune system in determining the risk of developing infections; such microbial interactions may modulate the expression of the infection, change the microbial pathogenicity, or increase the immunosuppression.
2015
β-herpesviruses cytomegalovirus fungal infection human herpesvirus 6 human herpesvirus 7 innate immune system microbiome solid organ transplant stem cell transplant viral–fungal interactions
01 Pubblicazione su rivista::01a Articolo in rivista
Interplay between β herpesviruses and fungal infections in transplant patients: from the bench to the bedside / Gentile, Giuseppe; Antonelli, Guido. - In: FUTURE VIROLOGY. - ISSN 1746-0794. - STAMPA. - 10:4(2015), pp. 399-414. [10.2217/fvl.15.4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/788240
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