Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation. Besides their participation to normal physiology, lncRNA expression and function have been already associated to cancer development and progression. Here, we review the functional role and mechanisms of action of lncRNAs in normal hematopoiesis and how their misregulation may be implicated in the development of blood cell cancer, such as leukemia.

Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia / Morlando, Mariangela; Ballarino, Monica; Fatica, Alessandro. - In: FRONTIERS IN MEDICINE. - ISSN 2296-858X. - ELETTRONICO. - 2:(2015). [10.3389/fmed.2015.00023]

Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia

MORLANDO, MARIANGELA;BALLARINO, MONICA;FATICA, Alessandro
2015

Abstract

Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation. Besides their participation to normal physiology, lncRNA expression and function have been already associated to cancer development and progression. Here, we review the functional role and mechanisms of action of lncRNAs in normal hematopoiesis and how their misregulation may be implicated in the development of blood cell cancer, such as leukemia.
2015
lncRNA; leukemia; hematopoiesis
01 Pubblicazione su rivista::01a Articolo in rivista
Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia / Morlando, Mariangela; Ballarino, Monica; Fatica, Alessandro. - In: FRONTIERS IN MEDICINE. - ISSN 2296-858X. - ELETTRONICO. - 2:(2015). [10.3389/fmed.2015.00023]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/785291
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