Anthraquinone compound aloe-emodin (AE) has shown antineoplastic, antibacterial, antiviral, and antiinflammatory properties and scavenging activity on free radicals. Because of these therapeutic features, AE has been attracting increasing interest and could be applied in the curing of many diseases. However, until now the physicochemical features of this compound have not been fully investigated; furthermore, its wide application might be hindered by its scarce solubility in aqueous media (∼19 μM). The inclusion of AE in nanocarriers, such as cationic liposomes, could allow its delivery effectively and selectively to target sites, reducing side effects in the remaining tissues. In this work, the weak acid nature of AE, because of its two phenolic functions, was exploited to load it remotely in the internal aqueous phase of liposomes in response to a difference in pH between the inside and outside of the liposomes, pHin > pHout. The inclusion of AE in gemini-based cationic liposomes by

Remote loading of aloe emodin in gemini-based cationic Liposomes / Giuliani, Chiara; Barbara, Altieri; Cecilia, Bombelli; Galantini, Luciano; Giovanna, Mancini; Annarita, Stringaro. - In: LANGMUIR. - ISSN 0743-7463. - 31:1(2015), pp. 76-82. [10.1021/la5038074]

Remote loading of aloe emodin in gemini-based cationic Liposomes

Chiara Giuliani;GALANTINI, Luciano;
2015

Abstract

Anthraquinone compound aloe-emodin (AE) has shown antineoplastic, antibacterial, antiviral, and antiinflammatory properties and scavenging activity on free radicals. Because of these therapeutic features, AE has been attracting increasing interest and could be applied in the curing of many diseases. However, until now the physicochemical features of this compound have not been fully investigated; furthermore, its wide application might be hindered by its scarce solubility in aqueous media (∼19 μM). The inclusion of AE in nanocarriers, such as cationic liposomes, could allow its delivery effectively and selectively to target sites, reducing side effects in the remaining tissues. In this work, the weak acid nature of AE, because of its two phenolic functions, was exploited to load it remotely in the internal aqueous phase of liposomes in response to a difference in pH between the inside and outside of the liposomes, pHin > pHout. The inclusion of AE in gemini-based cationic liposomes by
2015
.
01 Pubblicazione su rivista::01a Articolo in rivista
Remote loading of aloe emodin in gemini-based cationic Liposomes / Giuliani, Chiara; Barbara, Altieri; Cecilia, Bombelli; Galantini, Luciano; Giovanna, Mancini; Annarita, Stringaro. - In: LANGMUIR. - ISSN 0743-7463. - 31:1(2015), pp. 76-82. [10.1021/la5038074]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/784238
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