Abstract This study investigates how cognitive reserve (CR) interacts with neurodegeneration (quantified by medial temporal atrophy, MTA) and macroscopic white matter lesions (WMLs) in delaying the conversion from amnestic mild cognitive impairment to Alzheimer's disease (AD). Forty-two amnestic mild cognitive impairment patients were consecutively recruited. They underwent magnetic resonance imaging and a comprehensive questionnaire to classify them as individuals with low or high CR. Patients were then clinically followed-up for 2 years. The patients' risk for conversion to AD because of CR was estimated by controlling for cognitive efficiency, MTA, and WMLs at baseline. Global cognition was the best predictor of conversion to AD in low CR patients. Conversely, in high CR patients only, WMLs (but not MTA) highly contributed in increasing the risk for conversion to AD. In conclusion, CR interacts with both patients' cognitive features and WMLs in modulating the impact of AD pathology. This seems relevant for clinical prognosis and therapeutic strategies.

Cognitive reserve and the risk for alzheimer's disease. a longitudinal study / Serra, L; Musicco, M; Cercignani, M; Torso, M; Spanò, B; Mastropasqua, C; Giulietti, G; Marra, C; Bruno, Giuseppe; Koch, G; Caltagirone, C; Bozzali, M.. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - STAMPA. - 36:2(2015), pp. 592-600. [10.1016/j.neurobiolaging.2014.10.010]

Cognitive reserve and the risk for alzheimer's disease. a longitudinal study

Giulietti G;BRUNO, Giuseppe;
2015

Abstract

Abstract This study investigates how cognitive reserve (CR) interacts with neurodegeneration (quantified by medial temporal atrophy, MTA) and macroscopic white matter lesions (WMLs) in delaying the conversion from amnestic mild cognitive impairment to Alzheimer's disease (AD). Forty-two amnestic mild cognitive impairment patients were consecutively recruited. They underwent magnetic resonance imaging and a comprehensive questionnaire to classify them as individuals with low or high CR. Patients were then clinically followed-up for 2 years. The patients' risk for conversion to AD because of CR was estimated by controlling for cognitive efficiency, MTA, and WMLs at baseline. Global cognition was the best predictor of conversion to AD in low CR patients. Conversely, in high CR patients only, WMLs (but not MTA) highly contributed in increasing the risk for conversion to AD. In conclusion, CR interacts with both patients' cognitive features and WMLs in modulating the impact of AD pathology. This seems relevant for clinical prognosis and therapeutic strategies.
2015
cognitive reserve; a mci; ad; relative risk; mta; white matter lesions
01 Pubblicazione su rivista::01a Articolo in rivista
Cognitive reserve and the risk for alzheimer's disease. a longitudinal study / Serra, L; Musicco, M; Cercignani, M; Torso, M; Spanò, B; Mastropasqua, C; Giulietti, G; Marra, C; Bruno, Giuseppe; Koch, G; Caltagirone, C; Bozzali, M.. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - STAMPA. - 36:2(2015), pp. 592-600. [10.1016/j.neurobiolaging.2014.10.010]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/784192
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