ORAL PRESENTATION In this work, a new millifluidic continuous flow-through device is proposed for dissolution studies of oral dissolving strips. The flow-through device mimics mouth physiological conditions thanks to the laminar tangential solvent flow, flow rates order of 1 mL/min and low holdup volume (1 cm3 ). Pilot dissolution tests have been performed on commercially available melatonin strips with different initial drug loadings and thicknesses. Dissolution profiles obtained with the flow-through device are compared with those obtained using the official USP XXXVII basket (USP 1) and paddle (USP 2) apparatuses.

In-vitro dissolution testing of oral thin films (OTFs): theory and experiments ORAL PRESENTATION

ADROVER, Alessandra;CASADEI, Maria Antonietta;PACELLI, SETTIMIO;PAOLICELLI, PATRIZIA;PETRALITO, Stefania;SPERA, ROMINA
2015

Abstract

ORAL PRESENTATION In this work, a new millifluidic continuous flow-through device is proposed for dissolution studies of oral dissolving strips. The flow-through device mimics mouth physiological conditions thanks to the laminar tangential solvent flow, flow rates order of 1 mL/min and low holdup volume (1 cm3 ). Pilot dissolution tests have been performed on commercially available melatonin strips with different initial drug loadings and thicknesses. Dissolution profiles obtained with the flow-through device are compared with those obtained using the official USP XXXVII basket (USP 1) and paddle (USP 2) apparatuses.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/784128
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