Methylphenidate (MPD) is a central nervous system (CNS) stimulant, which belongs to the phenethylamine group and is mainly used in the treatment of attention deficit hyperactive disorder (ADHD). However, a growing number of young individuals misuse or abuse MPD to sustain attention, enhance intellectual capacity and increase memory. Recently, the use of MPD as a cognitive enhancement substance has received much attention and raised concerns in the literature and academic circles worldwide. The prescribing frequency of the drug has increased sharply asconsequence of the more accurate diagnosis of the ADHD and the popularity of the drug itself due to its beneficial short-term effect. However, careful monitoring is required, because of possible abuse. In this review different aspects concerning the use of MPD have been approached. Data showing its abuse among college students are given, when the drug is prescribed short term beneficial effects and side effects are provided; moreover studies on animal-models suggesting long lasting negative effects on healthy brains are discussed. Finally, emphasis is given to the available formulationsand pharmacology.

From clinical application to cognitive enhancement: the example of methylphenidate / Busardo', FRANCESCO PAOLO; Kyriakou, Chrystalla; Cipolloni, Luigi; Zaami, Simona; Frati, Paola. - In: CURRENT NEUROPHARMACOLOGY. - ISSN 1570-159X. - STAMPA. - 14:1(2016), pp. 17-27. [10.2174/1570159X13666150407225902]

From clinical application to cognitive enhancement: the example of methylphenidate

BUSARDO', FRANCESCO PAOLO;KYRIAKOU, CHRYSTALLA;CIPOLLONI, LUIGI;ZAAMI, Simona;FRATI, PAOLA
2016

Abstract

Methylphenidate (MPD) is a central nervous system (CNS) stimulant, which belongs to the phenethylamine group and is mainly used in the treatment of attention deficit hyperactive disorder (ADHD). However, a growing number of young individuals misuse or abuse MPD to sustain attention, enhance intellectual capacity and increase memory. Recently, the use of MPD as a cognitive enhancement substance has received much attention and raised concerns in the literature and academic circles worldwide. The prescribing frequency of the drug has increased sharply asconsequence of the more accurate diagnosis of the ADHD and the popularity of the drug itself due to its beneficial short-term effect. However, careful monitoring is required, because of possible abuse. In this review different aspects concerning the use of MPD have been approached. Data showing its abuse among college students are given, when the drug is prescribed short term beneficial effects and side effects are provided; moreover studies on animal-models suggesting long lasting negative effects on healthy brains are discussed. Finally, emphasis is given to the available formulationsand pharmacology.
2016
abuse; ADHD; cognitive enhancement; long-term effects; methylphenidate
01 Pubblicazione su rivista::01a Articolo in rivista
From clinical application to cognitive enhancement: the example of methylphenidate / Busardo', FRANCESCO PAOLO; Kyriakou, Chrystalla; Cipolloni, Luigi; Zaami, Simona; Frati, Paola. - In: CURRENT NEUROPHARMACOLOGY. - ISSN 1570-159X. - STAMPA. - 14:1(2016), pp. 17-27. [10.2174/1570159X13666150407225902]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/783749
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