Natural killer (NK) cells are an essential component of innate immunity that can rapidly detect and respond to malignant or infected cells. Chemokines play important roles in directing immune responses by controlling tissue homing, retention, and activation of immune cells. Although some chemokines can promote tumor growth and metastasis, others are responsible for extensive infiltration of lymphocytes, thus resulting in a protective anti-tumor immune response. Here, we summarize discoveries that have revealed the role of specific chemokines in regulating the function of NK cells during inflammation, infection, and malignancies.

The pathophysiological role of Chemokines in the regulation of NK cell tissue homing / Bernardini, Giovanni; Santoni, Angela. - In: CRITICAL REVIEWS IN ONCOGENESIS. - ISSN 0893-9675. - 19:(2014), pp. 77-90. [10.1615/CritRevOncog.2014010386]

The pathophysiological role of Chemokines in the regulation of NK cell tissue homing

BERNARDINI, Giovanni;SANTONI, Angela
2014

Abstract

Natural killer (NK) cells are an essential component of innate immunity that can rapidly detect and respond to malignant or infected cells. Chemokines play important roles in directing immune responses by controlling tissue homing, retention, and activation of immune cells. Although some chemokines can promote tumor growth and metastasis, others are responsible for extensive infiltration of lymphocytes, thus resulting in a protective anti-tumor immune response. Here, we summarize discoveries that have revealed the role of specific chemokines in regulating the function of NK cells during inflammation, infection, and malignancies.
2014
Chemokines; Tumor; Natural Killer Cells
01 Pubblicazione su rivista::01a Articolo in rivista
The pathophysiological role of Chemokines in the regulation of NK cell tissue homing / Bernardini, Giovanni; Santoni, Angela. - In: CRITICAL REVIEWS IN ONCOGENESIS. - ISSN 0893-9675. - 19:(2014), pp. 77-90. [10.1615/CritRevOncog.2014010386]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/783677
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