The presence of new hypotensive peptides, possibly not related to ACE inhibition, has been investigated on 66 snake venoms from crotalid, viperid and elapid families. Only the venom of Crotalus atrox showed a substantial amount of a new decapeptide, called POL-236, with the following aminoacid sequence: PYR-LEU-TRP-PRO-ARG-PRO-GLN-ILE-PRO-PRO. Pharmacological assays performed on the synthesized peptide revealed effects on blood pressure, probably derived from vascular and cardiac interferences.

A new peptide from Crotalus atrox snake venom / Politi, V; DE LUCA, G; DI STAZIO, G; Schinina', Maria Eugenia; Bossa, Francesco. - In: PEPTIDES. - ISSN 0196-9781. - 6:(1985), pp. 343-346. [10.1016/0196-9781(85)90395-X]

A new peptide from Crotalus atrox snake venom

SCHININA', Maria Eugenia;BOSSA, Francesco
1985

Abstract

The presence of new hypotensive peptides, possibly not related to ACE inhibition, has been investigated on 66 snake venoms from crotalid, viperid and elapid families. Only the venom of Crotalus atrox showed a substantial amount of a new decapeptide, called POL-236, with the following aminoacid sequence: PYR-LEU-TRP-PRO-ARG-PRO-GLN-ILE-PRO-PRO. Pharmacological assays performed on the synthesized peptide revealed effects on blood pressure, probably derived from vascular and cardiac interferences.
1985
biopeptides; venom peptides; ACE inhibitors
01 Pubblicazione su rivista::01a Articolo in rivista
A new peptide from Crotalus atrox snake venom / Politi, V; DE LUCA, G; DI STAZIO, G; Schinina', Maria Eugenia; Bossa, Francesco. - In: PEPTIDES. - ISSN 0196-9781. - 6:(1985), pp. 343-346. [10.1016/0196-9781(85)90395-X]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/78328
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