Several studies have made important advances in elucidating the contribution of both C/EBPα and miR-125b into the molecular mechanisms of AML development. Our study implicates the transcription factor C/EBPα as a critical determinant of miR-125b expression in AML, supporting a model whereby C/EBPα functions to enhance miR-125b expression to regulate a group of genes whose deregulation leads to acute myeloid transformation.
The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPalpha / VARGAS ROMERO, PAULA ESTEFANIA; Cialfi, Samantha; Palermo, Rocco; DE BLASIO, Carlo; Checquolo, Saula; Bellavia, Diana; Chiaretti, Sabina; Foa, Roberto; Amadori, Alberto; Gulino, Alberto; Zardo, Giuseppe; Talora, Claudio; Screpanti, Isabella. - In: LEUKEMIA. - ISSN 0887-6924. - STAMPA. - 29:12(2015), pp. 2442-2445. [10.1038/leu.2015.117]
The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPalpha
Paula Vargas Romero;Samantha Cialfi;Rocco Palermo;Carlo De Blasio;Saula Checquolo;Diana Bellavia;Sabina Chiaretti;Roberto Foa;Alberto Amadori;Alberto Gulino;Giuseppe Zardo;Claudio Talora
;Isabella Screpanti
2015
Abstract
Several studies have made important advances in elucidating the contribution of both C/EBPα and miR-125b into the molecular mechanisms of AML development. Our study implicates the transcription factor C/EBPα as a critical determinant of miR-125b expression in AML, supporting a model whereby C/EBPα functions to enhance miR-125b expression to regulate a group of genes whose deregulation leads to acute myeloid transformation.File | Dimensione | Formato | |
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