Several studies have made important advances in elucidating the contribution of both C/EBPα and miR-125b into the molecular mechanisms of AML development. Our study implicates the transcription factor C/EBPα as a critical determinant of miR-125b expression in AML, supporting a model whereby C/EBPα functions to enhance miR-125b expression to regulate a group of genes whose deregulation leads to acute myeloid transformation.

The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPalpha / VARGAS ROMERO, PAULA ESTEFANIA; Cialfi, Samantha; Palermo, Rocco; DE BLASIO, Carlo; Checquolo, Saula; Bellavia, Diana; Chiaretti, Sabina; Foa, Roberto; Amadori, Alberto; Gulino, Alberto; Zardo, Giuseppe; Talora, Claudio; Screpanti, Isabella. - In: LEUKEMIA. - ISSN 0887-6924. - STAMPA. - 29:12(2015), pp. 2442-2445. [10.1038/leu.2015.117]

The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPalpha

Paula Vargas Romero;Samantha Cialfi;Rocco Palermo;Carlo De Blasio;Saula Checquolo;Diana Bellavia;Sabina Chiaretti;Roberto Foa;Alberto Amadori;Alberto Gulino;Giuseppe Zardo;Claudio Talora
;
Isabella Screpanti
2015

Abstract

Several studies have made important advances in elucidating the contribution of both C/EBPα and miR-125b into the molecular mechanisms of AML development. Our study implicates the transcription factor C/EBPα as a critical determinant of miR-125b expression in AML, supporting a model whereby C/EBPα functions to enhance miR-125b expression to regulate a group of genes whose deregulation leads to acute myeloid transformation.
File allegati a questo prodotto
File Dimensione Formato  
VargasRomero_Deregulated-expression.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 1.11 MB
Formato Adobe PDF
1.11 MB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/782968
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 28
social impact