Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to activate glutamate receptors, thus potentially influencing a large group of functions in the central nervous system (CNS). Migraine, a largely unknown pathology, is strictly related to the glutamate system in the CNS pathologic terms. Despite the large number of studies conducted on migraine etio-pathology, the kynurenine pathway has been only recently linked to this disease. Nonetheless, some evidence suggests an intriguing role for some kynurenines, and an exploratory study on the serum kynurenine level might be helpful to better understand possible alterations of the kynurenine pathway in patients suffering from migraine

Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important / Curto, Martina; Lionetto, L; Fazio, Francesco; Mitsikostas, Dd; Martelletti, Paolo. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1970-9366. - ELETTRONICO. - 10:4(2015), pp. 413-421. [10.1007/s11739-015-1208-6]

Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important

CURTO, MARTINA;FAZIO, FRANCESCO;MARTELLETTI, Paolo
2015

Abstract

Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to activate glutamate receptors, thus potentially influencing a large group of functions in the central nervous system (CNS). Migraine, a largely unknown pathology, is strictly related to the glutamate system in the CNS pathologic terms. Despite the large number of studies conducted on migraine etio-pathology, the kynurenine pathway has been only recently linked to this disease. Nonetheless, some evidence suggests an intriguing role for some kynurenines, and an exploratory study on the serum kynurenine level might be helpful to better understand possible alterations of the kynurenine pathway in patients suffering from migraine
2015
Migraine; Kynurenic acid; Kynurenine; Xanthurenic acid; Anthranilic acid; Quinolinic acid
01 Pubblicazione su rivista::01a Articolo in rivista
Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important / Curto, Martina; Lionetto, L; Fazio, Francesco; Mitsikostas, Dd; Martelletti, Paolo. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1970-9366. - ELETTRONICO. - 10:4(2015), pp. 413-421. [10.1007/s11739-015-1208-6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/781950
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