Abstract The in vitro eVect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. Concentrations of 106 M to 109 M were associated with a dose dependent inhibition of colony formation, with the most clinically important eVects seen on the earliest erythroid and granulocytemacrophage colonies. Because of the potential clinical implications of these observations, studies are needed to determine the eVects of dexamethasone on haematopoiesis in preterm infants.
In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infant / Papoff, Paola; Christensen, Rd; Harcum, J; Li, Y.. - In: ARCHIVES OF DISEASE IN CHILDHOOD. FETAL AND NEONATAL EDITION. - ISSN 1468-2052. - 78:(1998), pp. F67-F69.
In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infant
PAPOFF, PAOLA
;
1998
Abstract
Abstract The in vitro eVect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. Concentrations of 106 M to 109 M were associated with a dose dependent inhibition of colony formation, with the most clinically important eVects seen on the earliest erythroid and granulocytemacrophage colonies. Because of the potential clinical implications of these observations, studies are needed to determine the eVects of dexamethasone on haematopoiesis in preterm infants.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
