Objectives. To provide a comprehensive appraisal of the evidence from secondary research on cardiac regenerative therapy. Study Design and Setting. Overview of systematic reviews of controlled clinical trials concerning stem cell administration or mobilization in patients with cardiovascular disease. Results. After a systematic database search, we short-listed 41 reviews (660 patients). Twenty two (54%) reviews focused on acute myocardial infarction (AMI), 19 (46%) on chronic ischemic heart disease (IHD) or heart failure (HF), 29 (71%) on bone marrow-derived stem-cells (BMSC), and 36 (88%) to randomized trials only. Substantial variability among reviews was found for validity (AMSTAR score: median 9 [minimum 3]; 1st quartile 9; 3rd quartile 10; maximum11), effect estimates (change in ejection fraction from baseline to follow-up: 3.47% [0.02%; 2.90%; 4.22%; 6.11%]), and citations (Web of Science yearly citations: 4.1 [0; 2.2; 6.5; 68.9]). No significant association was found between these three features. However, reviews focusing on BMSC therapy had higher validity scores ( = 0.008) and showed more pronounced effect estimates ( = 0.002). Higher citations were associated with journal impact factor ( = 0.007), corresponding author from North America/Europe ( = 0.022), and inclusion of nonrandomized trials ( = 0.046). Conclusions. Substantial heterogeneity is apparent among these reviews in terms of quality and effect estimates.
State of the art on the evidence base in cardiac regenerative therapy. Overview of 41 systematic reviews / Peruzzi, Mariangela; DE FALCO, Elena; Antonio, Abbate; BIONDI ZOCCAI, Giuseppe; Chimenti, Isotta; Marzia, Lotrionte; Umberto, Benedetto; Ronak, Delewi; Marullo, Antonino; Frati, Giacomo. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6133. - ELETTRONICO. - 2015:(2015), pp. 1-7. [10.1155/2015/613782]
State of the art on the evidence base in cardiac regenerative therapy. Overview of 41 systematic reviews
PERUZZI, MARIANGELA;DE FALCO, ELENA;BIONDI ZOCCAI, GIUSEPPE;CHIMENTI, ISOTTA;MARULLO, Antonino;FRATI, GIACOMO
2015
Abstract
Objectives. To provide a comprehensive appraisal of the evidence from secondary research on cardiac regenerative therapy. Study Design and Setting. Overview of systematic reviews of controlled clinical trials concerning stem cell administration or mobilization in patients with cardiovascular disease. Results. After a systematic database search, we short-listed 41 reviews (660 patients). Twenty two (54%) reviews focused on acute myocardial infarction (AMI), 19 (46%) on chronic ischemic heart disease (IHD) or heart failure (HF), 29 (71%) on bone marrow-derived stem-cells (BMSC), and 36 (88%) to randomized trials only. Substantial variability among reviews was found for validity (AMSTAR score: median 9 [minimum 3]; 1st quartile 9; 3rd quartile 10; maximum11), effect estimates (change in ejection fraction from baseline to follow-up: 3.47% [0.02%; 2.90%; 4.22%; 6.11%]), and citations (Web of Science yearly citations: 4.1 [0; 2.2; 6.5; 68.9]). No significant association was found between these three features. However, reviews focusing on BMSC therapy had higher validity scores ( = 0.008) and showed more pronounced effect estimates ( = 0.002). Higher citations were associated with journal impact factor ( = 0.007), corresponding author from North America/Europe ( = 0.022), and inclusion of nonrandomized trials ( = 0.046). Conclusions. Substantial heterogeneity is apparent among these reviews in terms of quality and effect estimates.File | Dimensione | Formato | |
---|---|---|---|
Peruzzi_Cardiac-regenerative-therapy_2015.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
1.43 MB
Formato
Adobe PDF
|
1.43 MB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.