Broader comprehension of gene expression regulatory mechanisms can be gained from a global analysis of how transcription and degradation are coordinated to orchestrate complex cell responses. The role of messenger RNA (mRNA) turnover modulation in gene expression levels has become increasingly recognized. From such perspective, in this review we briefly illustrate how a simple but effective mathematical model of mRNA turnover and some experimental findings, may together shed light on the molecular mechanisms underpinning the major role of mRNA decay rates in shaping the kinetics of gene activation and repression.

Kinetic effects and modeling of mRNA turnover / M. C., Palumbo; Farina, Lorenzo; P., Paci. - In: WILEY INTERDISCIPLINARY REVIEWS. RNA. - ISSN 1757-7004. - STAMPA. - 3:6(2015), pp. 327-336. [10.1002/wrna.1277]

Kinetic effects and modeling of mRNA turnover

FARINA, Lorenzo
;
P. Paci
2015

Abstract

Broader comprehension of gene expression regulatory mechanisms can be gained from a global analysis of how transcription and degradation are coordinated to orchestrate complex cell responses. The role of messenger RNA (mRNA) turnover modulation in gene expression levels has become increasingly recognized. From such perspective, in this review we briefly illustrate how a simple but effective mathematical model of mRNA turnover and some experimental findings, may together shed light on the molecular mechanisms underpinning the major role of mRNA decay rates in shaping the kinetics of gene activation and repression.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/780523
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