Functional alterations of the autonomic nervous system have been described in relation to chronic hypoxemia in chronic obstructive pulmonary diseases. Aim of the present study was to investigate the occurrence of neuro-vegetative dysfunction during active tuberculosis in the absence of hypoxemia. Fifteen patients affected by pulmonary tuberculosis under standard therapy and 17 matched controls were enrolled. Activation of the sympathetic system was induced by the tilt-up test. Systolic and diastolic arterial pressures and the R-R interval were monitored for 15 min by Finapres and ECG. The baroreflex sensitivity was evaluated by the spontaneous sequences method. Systolic and diastolic pressures were significantly higher at basal conditions and showed a less increase during the tilt test in tuberculosis patients compared to healthy controls. The basal R-R interval was shorter and its reduction during the tilt test was less evident in patients. The baroreflex sensitivity was decreased in patients at basal conditions and its reduction during the tilt test was less evident than in controls. Our preliminary results suggest the presence in tuberculosis patients of an altered autonomic cardiovascular regulation, which is a reduced function of the baroreflex control of the sinus node.

Autonomic nervous system dysfunction in the course of active pulmonary tuberculosis / Raimondi, Gianfranco; Silvia, Contini; J. M., Legramante; Marialuisa, Bocchino; Sergio, Sacco; Marco, Pallante; Mario, Cazzola; Cesare, Saltini. - In: RESPIRATORY MEDICINE. - ISSN 0954-6111. - 101:8(2007), pp. 1804-1808. [10.1016/j.rmed.2007.02.008]

Autonomic nervous system dysfunction in the course of active pulmonary tuberculosis.

RAIMONDI, GIANFRANCO;
2007

Abstract

Functional alterations of the autonomic nervous system have been described in relation to chronic hypoxemia in chronic obstructive pulmonary diseases. Aim of the present study was to investigate the occurrence of neuro-vegetative dysfunction during active tuberculosis in the absence of hypoxemia. Fifteen patients affected by pulmonary tuberculosis under standard therapy and 17 matched controls were enrolled. Activation of the sympathetic system was induced by the tilt-up test. Systolic and diastolic arterial pressures and the R-R interval were monitored for 15 min by Finapres and ECG. The baroreflex sensitivity was evaluated by the spontaneous sequences method. Systolic and diastolic pressures were significantly higher at basal conditions and showed a less increase during the tilt test in tuberculosis patients compared to healthy controls. The basal R-R interval was shorter and its reduction during the tilt test was less evident in patients. The baroreflex sensitivity was decreased in patients at basal conditions and its reduction during the tilt test was less evident than in controls. Our preliminary results suggest the presence in tuberculosis patients of an altered autonomic cardiovascular regulation, which is a reduced function of the baroreflex control of the sinus node.
2007
01 Pubblicazione su rivista::01a Articolo in rivista
Autonomic nervous system dysfunction in the course of active pulmonary tuberculosis / Raimondi, Gianfranco; Silvia, Contini; J. M., Legramante; Marialuisa, Bocchino; Sergio, Sacco; Marco, Pallante; Mario, Cazzola; Cesare, Saltini. - In: RESPIRATORY MEDICINE. - ISSN 0954-6111. - 101:8(2007), pp. 1804-1808. [10.1016/j.rmed.2007.02.008]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/78046
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