ABSTRACT: Among the most interesting applications of ferromagnetic nanoparticles (NPs) in medicine is the potential for localizing pharmacologically or radioactively tagged agents directly to selected tissues selected by an adjustable external magnetic field. This concept is demonstrated by the application external magnetic field on IV Tc-labeled aminosilane-coated iron oxide NPs in a rat model. In a model comparing a rat with a 0.3-T magnet over a hind paw versus a rat without a magnet, a static acquisition at 45 minutes showed that 27% of the administered radioactivity was in the area subtended by the magnet, whereas the liver displays a percentage of binding of 14% in the presence of the magnet and of 16% in the absence of an external magnetic field. These preliminary results suggest that the application of an external magnetic field may be a viable route for the development of methods for the confinement of magnetic NPs labeled with radioactive isotopes targeted for predetermined sites of the body.
Effect of External Magnetic Field on IV 99mTc-Labeled Aminosilane-Coated Iron Oxide Nanoparticles: Demonstration in a Rat Model: Special Report / Liberatore, Mauro; Barteri, Mario; Megna, Valentina; Piera, D'Elia; Rebonato, Stefania; A., Latini; DE ANGELIS, Francesca; Scaramuzzo, FRANCESCA ANNA; DE STEFANO, Maria Egle; Guadagno, NOEMI ANTONELLA; S., Chondrogiannis; A. M., Maffione; D., Rubello; Pala, Alessandro; P. M., Colletti. - In: CLINICAL NUCLEAR MEDICINE. - ISSN 0363-9762. - ELETTRONICO. - 40:(2014), pp. e-104-e-110. [10.1097/rlu.0000000000000672]
Effect of External Magnetic Field on IV 99mTc-Labeled Aminosilane-Coated Iron Oxide Nanoparticles: Demonstration in a Rat Model: Special Report
LIBERATORE, Mauro;BARTERI, Mario;MEGNA, VALENTINA;REBONATO, STEFANIA;DE ANGELIS, FRANCESCA;SCARAMUZZO, FRANCESCA ANNA;DE STEFANO, Maria Egle;GUADAGNO, NOEMI ANTONELLA;PALA, Alessandro;
2014
Abstract
ABSTRACT: Among the most interesting applications of ferromagnetic nanoparticles (NPs) in medicine is the potential for localizing pharmacologically or radioactively tagged agents directly to selected tissues selected by an adjustable external magnetic field. This concept is demonstrated by the application external magnetic field on IV Tc-labeled aminosilane-coated iron oxide NPs in a rat model. In a model comparing a rat with a 0.3-T magnet over a hind paw versus a rat without a magnet, a static acquisition at 45 minutes showed that 27% of the administered radioactivity was in the area subtended by the magnet, whereas the liver displays a percentage of binding of 14% in the presence of the magnet and of 16% in the absence of an external magnetic field. These preliminary results suggest that the application of an external magnetic field may be a viable route for the development of methods for the confinement of magnetic NPs labeled with radioactive isotopes targeted for predetermined sites of the body.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
