Background: Collagen cross linking (CXL) of the cornea has been developed recently as a new treatment for multidrug-resistant infectious keratitis. The aim of this study is to summarize the previously published data and evaluate the effectiveness of this treatment. Results: The search identified 12 articles. The number of eyes was 104. The infectious keratitis was associated with bacteria in 58 eyes (57%): Gram-positive bacteria in 44 (43%; 4 of which were infected with Mycobacterium (3.6%)) and Gram-negative bacteria in 14 eyes (13%), fungus in 13 eyes (12%), and Acanthamoeba in 7 eyes (7%). In 26 eyes (25%), the microbiological culture was negative or not performed. The mean time of re-epithelization after CXL was 20.7 ± 28.1 days (minimum of 3, maximum of 145). Sixteen eyes underwent deep or lamellar keratoplasty. The pooled analysis suggested that CXL has a favorable effect on the block of corneal melting in 85% (95%; CI 0.77, 0.91) of eyes. Conclusion: Although randomized controll

Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases / Alio, Jl; Abbouda, Alessandro; Valle, Dd; Del Castillo, Jm; Fernandez, J. A.. - In: JOURNAL OF OPHTHALMIC INFLAMMATION AND INFECTION. - ISSN 1869-5760. - (2013). [10.1186/1869-5760-3-47]

Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases.

ABBOUDA, ALESSANDRO;
2013

Abstract

Background: Collagen cross linking (CXL) of the cornea has been developed recently as a new treatment for multidrug-resistant infectious keratitis. The aim of this study is to summarize the previously published data and evaluate the effectiveness of this treatment. Results: The search identified 12 articles. The number of eyes was 104. The infectious keratitis was associated with bacteria in 58 eyes (57%): Gram-positive bacteria in 44 (43%; 4 of which were infected with Mycobacterium (3.6%)) and Gram-negative bacteria in 14 eyes (13%), fungus in 13 eyes (12%), and Acanthamoeba in 7 eyes (7%). In 26 eyes (25%), the microbiological culture was negative or not performed. The mean time of re-epithelization after CXL was 20.7 ± 28.1 days (minimum of 3, maximum of 145). Sixteen eyes underwent deep or lamellar keratoplasty. The pooled analysis suggested that CXL has a favorable effect on the block of corneal melting in 85% (95%; CI 0.77, 0.91) of eyes. Conclusion: Although randomized controll
2013
01 Pubblicazione su rivista::01a Articolo in rivista
Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases / Alio, Jl; Abbouda, Alessandro; Valle, Dd; Del Castillo, Jm; Fernandez, J. A.. - In: JOURNAL OF OPHTHALMIC INFLAMMATION AND INFECTION. - ISSN 1869-5760. - (2013). [10.1186/1869-5760-3-47]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/780014
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