Starting from trifluoroacetaldehyde ethyl hemiacetal, chiral amines and suitable aldehydes, diastereomerically pure fluorinated syn- or anti-γ-amino alcohols can be obtained by a friendly one-pot solvent-free L-proline catalysed Mannich-type reaction only by changing the temperature.
Trifluoromethyl syn- or anti-γ-amino alcohols by one-pot solvent-free mannich-type reactions under temperature control / Fioravanti, Stefania; L., Parise; Pelagalli, Alessia; Pellacani, Lucio; Trulli, Laura. - In: RSC ADVANCES. - ISSN 2046-2069. - STAMPA. - 5:37(2015), pp. 29312-29318. [10.1039/C5RA01791B]
Trifluoromethyl syn- or anti-γ-amino alcohols by one-pot solvent-free mannich-type reactions under temperature control
FIORAVANTI, Stefania
Primo
;PELAGALLI, ALESSIA;PELLACANI, LucioPenultimo
;TRULLI, LAURAUltimo
2015
Abstract
Starting from trifluoroacetaldehyde ethyl hemiacetal, chiral amines and suitable aldehydes, diastereomerically pure fluorinated syn- or anti-γ-amino alcohols can be obtained by a friendly one-pot solvent-free L-proline catalysed Mannich-type reaction only by changing the temperature.File allegati a questo prodotto
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