Abstract OBJECTIVE: Aim of this study is to evaluate whether Myasthenia Gravis (MG) might influence Overall Survival (OS) and Cumulative Incidence of Recurrence (CIR) in thymoma patients. METHODS: this is a multicenter retrospective study of patients operated in 6 high-volume Italian Institutions between 1990 and 2012. OS was estimated by the Kaplan-Meier method and CIR by considering death from any cause as a competing event. Crude and adjusted comparisons by MG for OS and CIR were performed using Cox and Fine&Gray models. Adjusted models included MG, age, gender, stage, histology, induction therapy, completeness of resection, adjuvant therapy. RESULTS: Seven hundred ninety-seven patients were included: 375 (47%) had MG. MG patients were younger and more frequently female, with a B2-B3 thymoma. At the end of the study, 129 patients (54 with MG) developed a recurrence and 165 (66 with MG) died. At univariate analysis, MG showed a slight protective effect on OS, not confirmed by the

Does myasthenia gravis influence overall survival and cumulative incidence of recurrence in thymoma patients? A Retrospective clinicopathological multicentre analysis on 797 patients / Filosso, Pl; Evangelista, A; Ruffini, E; Rendina, Erino Angelo; Margaritora, S; Novellis, P; Rena, O; Casadio, C; Andreetti, Claudio; Guerrera, F; Lausi, Po; Diso, Daniele; Mussi, A; Venuta, Federico; Oliaro, A; Lucchi, M.. - In: LUNG CANCER. - ISSN 0169-5002. - 88:3(2015), pp. 338-343. [10.1016/j]

Does myasthenia gravis influence overall survival and cumulative incidence of recurrence in thymoma patients? A Retrospective clinicopathological multicentre analysis on 797 patients.

RENDINA, Erino Angelo;ANDREETTI, Claudio;DISO, DANIELE;VENUTA, Federico;
2015

Abstract

Abstract OBJECTIVE: Aim of this study is to evaluate whether Myasthenia Gravis (MG) might influence Overall Survival (OS) and Cumulative Incidence of Recurrence (CIR) in thymoma patients. METHODS: this is a multicenter retrospective study of patients operated in 6 high-volume Italian Institutions between 1990 and 2012. OS was estimated by the Kaplan-Meier method and CIR by considering death from any cause as a competing event. Crude and adjusted comparisons by MG for OS and CIR were performed using Cox and Fine&Gray models. Adjusted models included MG, age, gender, stage, histology, induction therapy, completeness of resection, adjuvant therapy. RESULTS: Seven hundred ninety-seven patients were included: 375 (47%) had MG. MG patients were younger and more frequently female, with a B2-B3 thymoma. At the end of the study, 129 patients (54 with MG) developed a recurrence and 165 (66 with MG) died. At univariate analysis, MG showed a slight protective effect on OS, not confirmed by the
2015
Myasthenia Gravis; Paraneoplastic syndrome; Recurrence; Surgery; Survival; Thymoma
01 Pubblicazione su rivista::01a Articolo in rivista
Does myasthenia gravis influence overall survival and cumulative incidence of recurrence in thymoma patients? A Retrospective clinicopathological multicentre analysis on 797 patients / Filosso, Pl; Evangelista, A; Ruffini, E; Rendina, Erino Angelo; Margaritora, S; Novellis, P; Rena, O; Casadio, C; Andreetti, Claudio; Guerrera, F; Lausi, Po; Diso, Daniele; Mussi, A; Venuta, Federico; Oliaro, A; Lucchi, M.. - In: LUNG CANCER. - ISSN 0169-5002. - 88:3(2015), pp. 338-343. [10.1016/j]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/778338
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