CONTEXT: There is a need for the discovery of novel natural remedies to prevent and treat metabolic disorders such as hyperglycemia, type II non-insulin-dependent diabetes mellitus, and obesity. Several Achillea species have been utilized for centuries all around the world and are generally considered effective as hypoglycemic. OBJECTIVE: Considering the ethnobotanical uses of Achillea genus, we evaluated the in vitro inhibitory activity of Achillea tenorii Grande (Asteraceae) extract on α-glucosidase, which is a valuable target to prevent and treat metabolic disorders. We also tested its antioxidant activity. Moreover, the phytochemical profile was discussed from a chemotaxonomic point of view. MATERIALS AND METHODS: In vitro α-glucosidase inhibition of crude ethanolic extract obtained from the aerial parts was assayed as well as the in vitro antioxidant activity (ABTS, DPPH, and FRAP-FZ tests) was measured. The extract was characterized from a phytochemical point of view by means of spectroscopic analysis. +RESULTS: The extract results endowed with α-glucosidase inhibitory activity (IC50 32 µg/mL) with a particular mechanism of action definable as un-competitive, which differed from the mechanism observed for the best-known α-glucosidase inhibitor (acarbose and miglitol). In addition, a considerable antioxidant potential has been found for A. tenorii extract, which resulted mainly constituted by phenolic compounds such as caffeoylquinic acids and flavonoids. DISCUSSION AND CONCLUSIONS: These results suggest the potential of A. tenorii as a possible natural remedy to prevent and treat metabolic disorders of carbohydrates.

Antioxidant and α-glucosidase inhibitory activities of Achillea tenorii / Venditti, Alessandro; Filippo, Maggi; Sauro, Vittori; Fabrizio, Papa; Serrilli, ANNA MARIA; Mirella Di, Cecco; Gianpiero, Ciaschetti; Manuela, Mandrone; Ferruccio, Poli; Bianco, Armandodoriano. - In: PHARMACEUTICAL BIOLOGY. - ISSN 1388-0209. - STAMPA. - 53:10(2015), pp. 1505-1510. [10.3109/13880209.2014.991833]

Antioxidant and α-glucosidase inhibitory activities of Achillea tenorii

VENDITTI, ALESSANDRO
;
SERRILLI, ANNA MARIA;BIANCO, Armandodoriano
2015

Abstract

CONTEXT: There is a need for the discovery of novel natural remedies to prevent and treat metabolic disorders such as hyperglycemia, type II non-insulin-dependent diabetes mellitus, and obesity. Several Achillea species have been utilized for centuries all around the world and are generally considered effective as hypoglycemic. OBJECTIVE: Considering the ethnobotanical uses of Achillea genus, we evaluated the in vitro inhibitory activity of Achillea tenorii Grande (Asteraceae) extract on α-glucosidase, which is a valuable target to prevent and treat metabolic disorders. We also tested its antioxidant activity. Moreover, the phytochemical profile was discussed from a chemotaxonomic point of view. MATERIALS AND METHODS: In vitro α-glucosidase inhibition of crude ethanolic extract obtained from the aerial parts was assayed as well as the in vitro antioxidant activity (ABTS, DPPH, and FRAP-FZ tests) was measured. The extract was characterized from a phytochemical point of view by means of spectroscopic analysis. +RESULTS: The extract results endowed with α-glucosidase inhibitory activity (IC50 32 µg/mL) with a particular mechanism of action definable as un-competitive, which differed from the mechanism observed for the best-known α-glucosidase inhibitor (acarbose and miglitol). In addition, a considerable antioxidant potential has been found for A. tenorii extract, which resulted mainly constituted by phenolic compounds such as caffeoylquinic acids and flavonoids. DISCUSSION AND CONCLUSIONS: These results suggest the potential of A. tenorii as a possible natural remedy to prevent and treat metabolic disorders of carbohydrates.
phytochemical profile; type II diabetes; un-competitive α-glucosidase inhibition
01 Pubblicazione su rivista::01a Articolo in rivista
Antioxidant and α-glucosidase inhibitory activities of Achillea tenorii / Venditti, Alessandro; Filippo, Maggi; Sauro, Vittori; Fabrizio, Papa; Serrilli, ANNA MARIA; Mirella Di, Cecco; Gianpiero, Ciaschetti; Manuela, Mandrone; Ferruccio, Poli; Bianco, Armandodoriano. - In: PHARMACEUTICAL BIOLOGY. - ISSN 1388-0209. - STAMPA. - 53:10(2015), pp. 1505-1510. [10.3109/13880209.2014.991833]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/778129
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