Calixarenes derivatives 1 and 2, featuring two guanidine units at the upper rim, catalyze the transesteri ﬁ cation of diribonucleoside monophosphates much more e ﬀ ectively than that of HPNP. Rate accelerations relative to the background range from 10^3 to 10^4-fold, and approach 10^5-fold with the most favorable substrate-catalyst combinations.
Diguanidinocalixarenes as effective and selective catalysts of the cleavage of diribonucleoside monophosphates / Salvio, Riccardo; Roberta, Cacciapaglia; Mandolini, Luigi; Francesco, Sansone; Alessandro, Casnati. - In: RSC ADVANCES. - ISSN 2046-2069. - STAMPA. - 4:(2014), pp. 34412-34416. [10.1039/C4RA05751A]