Some linear D,L-peptides with regular enantiomeric sequences that act as potential ligands to the glycan portion of HIV-1 gp120 are identified. The aim of this work is to improve the binding affinity and specificity of such structures as well as their pharmacokinetic properties through medicinal chemistry efforts, using an effective and very versatile method of synthesis that gives easy access to the proposed structures which may also be subjected to further modifications.
D,L peptides as strong inhibitors of HIV-1 GP120 / Punzi, Pasqualina; C., Giordano; Morosetti, Stefano; P., De Santis; Silvestri, Romano; Scipioni, Anita. - STAMPA. - 1:(2013), pp. 11-11. (Intervento presentato al convegno XXII National Meeting on Medicinal Chemistry NMMC 2013 tenutosi a Roma nel 10-13 Settembre 2013).
D,L peptides as strong inhibitors of HIV-1 GP120.
PUNZI, PASQUALINA;MOROSETTI, Stefano;SILVESTRI, Romano;SCIPIONI, Anita
2013
Abstract
Some linear D,L-peptides with regular enantiomeric sequences that act as potential ligands to the glycan portion of HIV-1 gp120 are identified. The aim of this work is to improve the binding affinity and specificity of such structures as well as their pharmacokinetic properties through medicinal chemistry efforts, using an effective and very versatile method of synthesis that gives easy access to the proposed structures which may also be subjected to further modifications.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
