By flux analysis one generically indicates a class of constraint-based approaches to the study of biochemical reaction networks concerned with the calculation of the flux configurations compatible with given stoichiometric and thermodynamic constraints. One of its main areas of application is the study of cellular metabolic networks. We briefly and selectively review the main approaches to this problem and then, building on recent work, we provide a characterization of the productive capabilities of the metabolic network of the bacterium E.coli in a specified growth medium in terms of the producible biochemical species. While a robust and physiologically meaningful production profile clearly emerges, the underlying constraints still allow for significant fluctuations in the net production even for key metabolites like ATP and, as a consequence, apparently lay the ground for different growth scenarios.

The solution space of metabolic networks: producibility, robustness and fluctuations / A., De Martino; Marinari, Vincenzo. - In: JOURNAL OF PHYSICS. CONFERENCE SERIES. - ISSN 1742-6588. - 233:(2010), pp. 012019:1-012019:11. (Intervento presentato al convegno International Workshop on Statistical-Mechanical Informatics 2010 (IW-SMI 2010) tenutosi a Kyoto, JAPAN nel MAR 07-10, 2010) [10.1088/1742-6596/233/1/012019].

The solution space of metabolic networks: producibility, robustness and fluctuations

MARINARI, Vincenzo
2010

Abstract

By flux analysis one generically indicates a class of constraint-based approaches to the study of biochemical reaction networks concerned with the calculation of the flux configurations compatible with given stoichiometric and thermodynamic constraints. One of its main areas of application is the study of cellular metabolic networks. We briefly and selectively review the main approaches to this problem and then, building on recent work, we provide a characterization of the productive capabilities of the metabolic network of the bacterium E.coli in a specified growth medium in terms of the producible biochemical species. While a robust and physiologically meaningful production profile clearly emerges, the underlying constraints still allow for significant fluctuations in the net production even for key metabolites like ATP and, as a consequence, apparently lay the ground for different growth scenarios.
2010
International Workshop on Statistical-Mechanical Informatics 2010 (IW-SMI 2010)
04 Pubblicazione in atti di convegno::04c Atto di convegno in rivista
The solution space of metabolic networks: producibility, robustness and fluctuations / A., De Martino; Marinari, Vincenzo. - In: JOURNAL OF PHYSICS. CONFERENCE SERIES. - ISSN 1742-6588. - 233:(2010), pp. 012019:1-012019:11. (Intervento presentato al convegno International Workshop on Statistical-Mechanical Informatics 2010 (IW-SMI 2010) tenutosi a Kyoto, JAPAN nel MAR 07-10, 2010) [10.1088/1742-6596/233/1/012019].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/76798
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