The aim of the present study was to investigate P300 event-related potential components in euthymic bipolar disorder type I (BDI) and bipolar disorder type II (BDII) patients and matched controls. A total of 10 BDI patients, 10 BDII patients and 10 healthy individuals were enrolled in the study. Event-related potential data were collected according to a standard auditory 'oddball' paradigm. A significant groups effect in both the peak amplitude (P<0.001) and the mean amplitude (P<0.001) was observed; post-hoc comparisons showed that the peak and mean amplitudes of BDI and BDII patients were significantly lower than the peak and mean amplitudes of the healthy controls. The neurophysiological patterns found in the present study might at least partially reflect the presence of a mild selective cognitive impairment in euthymic BDI and BDII patients. From a clinical point of view, these evidences support the potential role of cognitive interventions in the treatment of BD.

P300 component in euthymic patients with bipolar disorder type I, bipolar disorder type II and healthy controls: a preliminary event-related potential study / Bersani, FRANCESCO SAVERIO; Minichino, Amedeo; Fattapposta, Francesco; Mannarelli, Daniela; Pauletti, Caterina; C., Imperatori; F., Spagnoli; Biondi, Massimo; DELLE CHIAIE, Roberto. - In: NEUROREPORT. - ISSN 0959-4965. - STAMPA. - 26:4(2015), pp. 206-210. [10.1097/WNR.0000000000000329]

P300 component in euthymic patients with bipolar disorder type I, bipolar disorder type II and healthy controls: a preliminary event-related potential study

BERSANI, FRANCESCO SAVERIO;MINICHINO, AMEDEO;FATTAPPOSTA, FRANCESCO;MANNARELLI, DANIELA;PAULETTI, CATERINA;BIONDI, Massimo;DELLE CHIAIE, ROBERTO
2015

Abstract

The aim of the present study was to investigate P300 event-related potential components in euthymic bipolar disorder type I (BDI) and bipolar disorder type II (BDII) patients and matched controls. A total of 10 BDI patients, 10 BDII patients and 10 healthy individuals were enrolled in the study. Event-related potential data were collected according to a standard auditory 'oddball' paradigm. A significant groups effect in both the peak amplitude (P<0.001) and the mean amplitude (P<0.001) was observed; post-hoc comparisons showed that the peak and mean amplitudes of BDI and BDII patients were significantly lower than the peak and mean amplitudes of the healthy controls. The neurophysiological patterns found in the present study might at least partially reflect the presence of a mild selective cognitive impairment in euthymic BDI and BDII patients. From a clinical point of view, these evidences support the potential role of cognitive interventions in the treatment of BD.
2015
P300; euthymic; bipolar disorder type II
01 Pubblicazione su rivista::01a Articolo in rivista
P300 component in euthymic patients with bipolar disorder type I, bipolar disorder type II and healthy controls: a preliminary event-related potential study / Bersani, FRANCESCO SAVERIO; Minichino, Amedeo; Fattapposta, Francesco; Mannarelli, Daniela; Pauletti, Caterina; C., Imperatori; F., Spagnoli; Biondi, Massimo; DELLE CHIAIE, Roberto. - In: NEUROREPORT. - ISSN 0959-4965. - STAMPA. - 26:4(2015), pp. 206-210. [10.1097/WNR.0000000000000329]
File allegati a questo prodotto
File Dimensione Formato  
Bersani_P300-euthymic-patients_2015.pdf

Open Access dal 27/02/2016

Note: Articolo principale
Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 124.12 kB
Formato Adobe PDF
124.12 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/764302
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 10
social impact