The aim of this study was to evaluate fibroblast growth factor (FGF)-23 serum levels and its tissue expression in patients with critical carotid artery stenosis (CAS). We selected 35 patients with critical CAS undergoing carotid thromboendoarterectomy. In each patient, FGF-23 serum levels were evaluated just prior to the surgery (t0) and 30 min (t1) thereafter. Moreover, macrophage cytokines were measured at baselines. Carotid artery specimens were used for immune histochemistry. On the basis of the histology, the patients were divided into 2 groups: A with complicated plaque and B with uncomplicated plaque. Twenty complicated plaques (57.14%, group A,) and 15 uncomplicated (42.86%, group B) were evaluated: calcifications were present in 16/20 (80%) complicated plaques and in 6/15 (40%) uncomplicated plaques. An inflammatory infiltrate was observed in 26/35 carotid samples: 18/26 (69.23%) complicated and 8/26 (30.76%) uncomplicated. FGF-23(+) cells were present in 17/20 complicated (85%) and in 8 uncomplicated (53%) plaques. The double-staining immunofluorescence confirmed that macrophage cells (CD68(+)) were also positive for FGF-23 staining. Serum levels of FGF-23 were significantly higher in group A versus group B at t0 (p < 0.05) and t1 (p 0.0047). Moreover, in group A patients a significant increase of FGF-23 serum levels was observed at t1 in comparison with t0 (p 0.0011). Our results suggest that FGF-23 acts in the late phases of atherosclerotic disease and may potentially represent a marker of complications in critical CAS.

FGF-23 levels in patients with critical carotid artery stenosis / DEL PORTO, Flavia; Proietta, M; DI GIOIA, Cira Rosaria Tiziana; Cifani, Noemi; Dito, Raffaele; Fantozzi, Cristiano; Ferri, Livia; Fabriani, L; Rossi, Michele; Tritapepe, Luigi; Taurino, Maurizio. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1970-9366. - STAMPA. - 10:4(2015), pp. 437-444. [10.1007/s11739-014-1183-3]

FGF-23 levels in patients with critical carotid artery stenosis

DEL PORTO, Flavia
Primo
;
DI GIOIA, Cira Rosaria Tiziana;CIFANI, NOEMI;DITO, RAFFAELE;FANTOZZI, CRISTIANO;FERRI, LIVIA;ROSSI, Michele;TRITAPEPE, Luigi
Penultimo
;
TAURINO, Maurizio
Ultimo
2015

Abstract

The aim of this study was to evaluate fibroblast growth factor (FGF)-23 serum levels and its tissue expression in patients with critical carotid artery stenosis (CAS). We selected 35 patients with critical CAS undergoing carotid thromboendoarterectomy. In each patient, FGF-23 serum levels were evaluated just prior to the surgery (t0) and 30 min (t1) thereafter. Moreover, macrophage cytokines were measured at baselines. Carotid artery specimens were used for immune histochemistry. On the basis of the histology, the patients were divided into 2 groups: A with complicated plaque and B with uncomplicated plaque. Twenty complicated plaques (57.14%, group A,) and 15 uncomplicated (42.86%, group B) were evaluated: calcifications were present in 16/20 (80%) complicated plaques and in 6/15 (40%) uncomplicated plaques. An inflammatory infiltrate was observed in 26/35 carotid samples: 18/26 (69.23%) complicated and 8/26 (30.76%) uncomplicated. FGF-23(+) cells were present in 17/20 complicated (85%) and in 8 uncomplicated (53%) plaques. The double-staining immunofluorescence confirmed that macrophage cells (CD68(+)) were also positive for FGF-23 staining. Serum levels of FGF-23 were significantly higher in group A versus group B at t0 (p < 0.05) and t1 (p 0.0047). Moreover, in group A patients a significant increase of FGF-23 serum levels was observed at t1 in comparison with t0 (p 0.0011). Our results suggest that FGF-23 acts in the late phases of atherosclerotic disease and may potentially represent a marker of complications in critical CAS.
2015
FGF-23; critical carotid artery stenosis; atherosclerosis; cytokines
01 Pubblicazione su rivista::01a Articolo in rivista
FGF-23 levels in patients with critical carotid artery stenosis / DEL PORTO, Flavia; Proietta, M; DI GIOIA, Cira Rosaria Tiziana; Cifani, Noemi; Dito, Raffaele; Fantozzi, Cristiano; Ferri, Livia; Fabriani, L; Rossi, Michele; Tritapepe, Luigi; Taurino, Maurizio. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1970-9366. - STAMPA. - 10:4(2015), pp. 437-444. [10.1007/s11739-014-1183-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/762252
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