Recent in vitro studies have suggested that autophagy may play a role in both HIV-1 replication and disease progression. In this study we investigated whether autophagy protects the small proportion of HIV-1 infected individuals who remain clinically stable for years in the absence of antiretroviral therapy, these named long-term nonprogressors (LTNP) and elite controllers (EC). We found that peripheral blood mononuclear cells (PBMC) of the HIV-1 controllers present a significantly higher amount of autophagic vesicles associated with an increased expression of autophagic markers with respect to normal progressors. Of note, ex vivo treatment of PBMC from the HIV-1 controllers with the MTOR inhibitor rapamycin results in a more efficient autophagic response, leading to a reduced viral production. These data lead us to propose that autophagy contributes to limiting viral pathogenesis in HIV-1 controllers by targeting viral components for degradation.

Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients / Nardacci, R; Amendola, A; Ciccosanti, F; Corazzari, M; Esposito, Valentina; Vlassi, C; Taibi, C; Fimia, Gm; Del Nonno, F; Ippolito, G; D'Offizi, G; Piacentini, M.. - In: AUTOPHAGY. - ISSN 1554-8627. - STAMPA. - 10:7(2014), pp. 1167-1178. [10.4161/auto.28678]

Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients.

ESPOSITO, VALENTINA;Fimia GM;
2014

Abstract

Recent in vitro studies have suggested that autophagy may play a role in both HIV-1 replication and disease progression. In this study we investigated whether autophagy protects the small proportion of HIV-1 infected individuals who remain clinically stable for years in the absence of antiretroviral therapy, these named long-term nonprogressors (LTNP) and elite controllers (EC). We found that peripheral blood mononuclear cells (PBMC) of the HIV-1 controllers present a significantly higher amount of autophagic vesicles associated with an increased expression of autophagic markers with respect to normal progressors. Of note, ex vivo treatment of PBMC from the HIV-1 controllers with the MTOR inhibitor rapamycin results in a more efficient autophagic response, leading to a reduced viral production. These data lead us to propose that autophagy contributes to limiting viral pathogenesis in HIV-1 controllers by targeting viral components for degradation.
2014
AMBRA1; ATG5; BECN1; HIV-1; autophagy
01 Pubblicazione su rivista::01a Articolo in rivista
Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients / Nardacci, R; Amendola, A; Ciccosanti, F; Corazzari, M; Esposito, Valentina; Vlassi, C; Taibi, C; Fimia, Gm; Del Nonno, F; Ippolito, G; D'Offizi, G; Piacentini, M.. - In: AUTOPHAGY. - ISSN 1554-8627. - STAMPA. - 10:7(2014), pp. 1167-1178. [10.4161/auto.28678]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/762111
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