Acute Lymphoblastic Leukemia (ALL) is an aggressive cancer that occurs in both children and adults. Starting from an integrated analysis of miRNA/mRNA expression profiles in 20 ALL patients, we identify a negative correlation between miR-181a and EGR1. Coherently, miR-181a over-expression in Jurkat T-ALL cells decreases EGR1 expression, increasing cell proliferation and enhancing the cell-cycle progression from G1 to S phase. We show that EGR1 is a new direct target of miR-181a. Our findings suggest that miR-181a behaves as an onco-miRNA in ALL by down-regulating EGR1.
microRNA-181a enhances cell proliferation in Acute Lymphoblastic Leukemia by targeting EGR1 / Verduci, Lorena; Azzalin, Gianluca; Gioiosa, Silvia; Carissimi, Claudia; Laudadio, Ilaria; Fulci, Valerio; Macino, Giuseppe. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - STAMPA. - (2015). [10.1016/j.leukres.2015.01.010]
microRNA-181a enhances cell proliferation in Acute Lymphoblastic Leukemia by targeting EGR1
VERDUCI, LORENA;AZZALIN, Gianluca;GIOIOSA, SILVIA;CARISSIMI, Claudia;LAUDADIO, ILARIA;FULCI, Valerio;MACINO, Giuseppe
2015
Abstract
Acute Lymphoblastic Leukemia (ALL) is an aggressive cancer that occurs in both children and adults. Starting from an integrated analysis of miRNA/mRNA expression profiles in 20 ALL patients, we identify a negative correlation between miR-181a and EGR1. Coherently, miR-181a over-expression in Jurkat T-ALL cells decreases EGR1 expression, increasing cell proliferation and enhancing the cell-cycle progression from G1 to S phase. We show that EGR1 is a new direct target of miR-181a. Our findings suggest that miR-181a behaves as an onco-miRNA in ALL by down-regulating EGR1.File | Dimensione | Formato | |
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