Intravenous immunoglobulin (IVIG) is widely used for the treatment of autoimmune and inflammatory disorders because of its immunomodulatory effects. The interaction of IVIG with the immune system has been extensively investigated over the past 30 years but, since IVIG modifies responses of many immune cells, a unifying model is far from reach. Here we survey the in vitro studies on the effects on IVIG on macrophages, B cells, T regulatory cells, dendritic cells and soluble factors, as well as the in vivo studies in murine disease models and the preliminary in vivo findings in humans.
Immunomodulatory effects of intravenous immunoglobulin - assembling a jigsaw puzzle / Mitrevski, Milica; Marrapodi, Ramona; Camponeschi, Alessandro; Todi, Laura; Granata, Guido; Maria Comasia, Leone; Fiorilli, Massimo. - In: INTERNATIONAL TRENDS IN IMMUNITY. - ISSN 2326-313X. - ELETTRONICO. - 2:2(2014), pp. 67-73.
Immunomodulatory effects of intravenous immunoglobulin - assembling a jigsaw puzzle
MITREVSKI, MILICA;MARRAPODI, RAMONA;CAMPONESCHI, ALESSANDRO;TODI, LAURA;GRANATA, GUIDO;FIORILLI, Massimo
2014
Abstract
Intravenous immunoglobulin (IVIG) is widely used for the treatment of autoimmune and inflammatory disorders because of its immunomodulatory effects. The interaction of IVIG with the immune system has been extensively investigated over the past 30 years but, since IVIG modifies responses of many immune cells, a unifying model is far from reach. Here we survey the in vitro studies on the effects on IVIG on macrophages, B cells, T regulatory cells, dendritic cells and soluble factors, as well as the in vivo studies in murine disease models and the preliminary in vivo findings in humans.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
