Introduction. Acute myeloid leukemia (AML) is caused by the clonal expansion of hematopoietic myeloid precursors blocked at different stages of differentiation. A subtype of AML, acute promyelocytic leukemia (APL), is a paradigm of differentiation therapy since all-transretinoic acid (ATRA)-based treatments are able to induce leukemic blast terminal differentiation, leading to clinical remission in the majority of APL patients. However, ATRA can lead to systemic toxicity and relapses after initial remission followed by resistance. Furthermore APL accounts for about 10-15% of AML cases and non-APL AML respond only very slightly to ATRA. Thus the search for a strategy to further sensitize AML cells to ATRA is highly needed. ATRA induces differentiation of APL blasts to granulocytes that are secretory cells since they are characterized by the presence of secretory granules containing peptides indispensable for their role in the immune response. The majority of proteins secreted or residen

CHARACTERIZATION OF THE UNFOLDED PROTEIN RESPONSE ROLE IN DIFFERENTIATION THERAPY OF ACUTE MYELOID LEUKEMIAS / Masciarelli, Silvia; Iosue', Ilaria; Fazi, Francesco. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 99, S2:(2014), pp. 63-63. (Intervento presentato al convegno XIII Congress of the Italian Society of Experimental Hematology tenutosi a Rimini, Italy nel October 15-17, 2014).

CHARACTERIZATION OF THE UNFOLDED PROTEIN RESPONSE ROLE IN DIFFERENTIATION THERAPY OF ACUTE MYELOID LEUKEMIAS

MASCIARELLI, SILVIA;IOSUE', ILARIA;FAZI, Francesco
2014

Abstract

Introduction. Acute myeloid leukemia (AML) is caused by the clonal expansion of hematopoietic myeloid precursors blocked at different stages of differentiation. A subtype of AML, acute promyelocytic leukemia (APL), is a paradigm of differentiation therapy since all-transretinoic acid (ATRA)-based treatments are able to induce leukemic blast terminal differentiation, leading to clinical remission in the majority of APL patients. However, ATRA can lead to systemic toxicity and relapses after initial remission followed by resistance. Furthermore APL accounts for about 10-15% of AML cases and non-APL AML respond only very slightly to ATRA. Thus the search for a strategy to further sensitize AML cells to ATRA is highly needed. ATRA induces differentiation of APL blasts to granulocytes that are secretory cells since they are characterized by the presence of secretory granules containing peptides indispensable for their role in the immune response. The majority of proteins secreted or residen
2014
XIII Congress of the Italian Society of Experimental Hematology
04 Pubblicazione in atti di convegno::04c Atto di convegno in rivista
CHARACTERIZATION OF THE UNFOLDED PROTEIN RESPONSE ROLE IN DIFFERENTIATION THERAPY OF ACUTE MYELOID LEUKEMIAS / Masciarelli, Silvia; Iosue', Ilaria; Fazi, Francesco. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 99, S2:(2014), pp. 63-63. (Intervento presentato al convegno XIII Congress of the Italian Society of Experimental Hematology tenutosi a Rimini, Italy nel October 15-17, 2014).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/759974
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