Cystic adrenal neoplasms are uncommon and may be incidentally discovered during radiologic procedure not directly performed for the evaluation of adrenal disease. Cystic pheochromocytomas are uncommon neoplasms that originate from the adrenal medulla, clinically differing from the more frequent solid pheochromocytomas. Here, we report a case of 72 year-old woman affected by asymptomatic pseudocystic pheochromocytoma (70x50mm), incidentally discovered, with a false negative 123I-monoiodobenzylguanidine (123I-MIBG) scintigraphy. Histopathological examination led to diagnosis of pseudocystic pheochromocytoma with typical architecture. The screening for germline mutation of succinate dehydrogenase complex subunits (SDHB, SDHC), Von Hipple-Lindau syndrome (VHL) and multiple endocrine neoplasia type 2 (RET) genes were negative, finding only some polymorphisms for RET and SDHB. We emphasize the relevance of an accurate pre-operative diagnosis, especially in rare diseases, and the requirement

Pseudocystic pheochromocytoma: An incidental finding and a rare entity / Petramala, Luigi; Zinnamosca, Laura; Marinelli, Cristiano; Calvieri, Camilla; Settevendemmie, A; Concistrè, A; Salvi, D; Ciardi, Antonio; D'Ermo, Giuseppe; DE TOMA, Giorgio; Letizia, Claudio. - In: JOURNAL OF CANCER RESEARCH & THERAPY. - ISSN 2052-4994. - 2:(2014), pp. 105-110. [10.14312/2052-4994.2014-16]

Pseudocystic pheochromocytoma: An incidental finding and a rare entity

PETRAMALA, LUIGI;ZINNAMOSCA, LAURA;MARINELLI, CRISTIANO;CALVIERI, CAMILLA;Concistrè A;CIARDI, Antonio;D'ERMO, Giuseppe;DE TOMA, Giorgio;LETIZIA, Claudio
2014

Abstract

Cystic adrenal neoplasms are uncommon and may be incidentally discovered during radiologic procedure not directly performed for the evaluation of adrenal disease. Cystic pheochromocytomas are uncommon neoplasms that originate from the adrenal medulla, clinically differing from the more frequent solid pheochromocytomas. Here, we report a case of 72 year-old woman affected by asymptomatic pseudocystic pheochromocytoma (70x50mm), incidentally discovered, with a false negative 123I-monoiodobenzylguanidine (123I-MIBG) scintigraphy. Histopathological examination led to diagnosis of pseudocystic pheochromocytoma with typical architecture. The screening for germline mutation of succinate dehydrogenase complex subunits (SDHB, SDHC), Von Hipple-Lindau syndrome (VHL) and multiple endocrine neoplasia type 2 (RET) genes were negative, finding only some polymorphisms for RET and SDHB. We emphasize the relevance of an accurate pre-operative diagnosis, especially in rare diseases, and the requirement
2014
adrenal cyst; pseudocystic pheochromocytoma; false-negative 123I-monoiodobenzylguanidine (MIBG) scintigraphy; adrenal incidentaloma
01 Pubblicazione su rivista::01a Articolo in rivista
Pseudocystic pheochromocytoma: An incidental finding and a rare entity / Petramala, Luigi; Zinnamosca, Laura; Marinelli, Cristiano; Calvieri, Camilla; Settevendemmie, A; Concistrè, A; Salvi, D; Ciardi, Antonio; D'Ermo, Giuseppe; DE TOMA, Giorgio; Letizia, Claudio. - In: JOURNAL OF CANCER RESEARCH & THERAPY. - ISSN 2052-4994. - 2:(2014), pp. 105-110. [10.14312/2052-4994.2014-16]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/759885
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