Helichrysum microphyllum Cambess. subsp. tyrrhenicum Bacch., Brullo e Giusso (Asteraceae), previously known as Helichrysum italicum ssp. microphyllum (Willd.) Nyman, is one of the many endemic species growing in Sardinia, Corsica and Balearic Islands. In the present work the composition of the essential oil obtained from a population of H. microphyllum ssp. thyrrenicum growing in a littoral location of La Maddalena Archipelago was investigated by GC-FID and CG-MS. The major compounds of the oil were the monoterpene ester neryl acetate (18.2%), the oxygenated sesquiterpene 5-eudesmen-11-ol (rosifoliol, 11.3%), the sequiterpene hydrocarbons delta-cadinene (8.4%) and gamma-cadinene (6.7%), showing a peculiar composition in comparison with other Sardinian populations. The oil was tested for cytotoxicity on three human tumor cell lines (MDA-MB 231, HCT116 and A375) by MTT assay showing a strong inhibitory activity on human malignant melanoma cells A375 (IC50 of 16 mu g/ml). In addition the oil was assessed for antioxidant activity by DPPH and ABTS assay.

Chemical composition and biological activity of the essential oil from Helichrysum microphyllum Cambess. ssp. tyrrhenicum Bacch., Brullo e Giusso growing in La Maddalena Archipelago, Sardinia / Ornano, Luigi; Venditti, Alessandro; Cinzia, Sanna; Mauro, Ballero; Filippo, Maggi; Giulio, Lupidi; Massimo, Bramucci; Luana, Quassinti; Bianco, Armandodoriano. - In: JOURNAL OF OLEO SCIENCE. - ISSN 1347-3352. - STAMPA. - 64:1(2015), pp. 19-26. [10.5650/jos.ess14171]

Chemical composition and biological activity of the essential oil from Helichrysum microphyllum Cambess. ssp. tyrrhenicum Bacch., Brullo e Giusso growing in La Maddalena Archipelago, Sardinia.

ORNANO, LUIGI;VENDITTI, ALESSANDRO
;
BIANCO, Armandodoriano
2015

Abstract

Helichrysum microphyllum Cambess. subsp. tyrrhenicum Bacch., Brullo e Giusso (Asteraceae), previously known as Helichrysum italicum ssp. microphyllum (Willd.) Nyman, is one of the many endemic species growing in Sardinia, Corsica and Balearic Islands. In the present work the composition of the essential oil obtained from a population of H. microphyllum ssp. thyrrenicum growing in a littoral location of La Maddalena Archipelago was investigated by GC-FID and CG-MS. The major compounds of the oil were the monoterpene ester neryl acetate (18.2%), the oxygenated sesquiterpene 5-eudesmen-11-ol (rosifoliol, 11.3%), the sequiterpene hydrocarbons delta-cadinene (8.4%) and gamma-cadinene (6.7%), showing a peculiar composition in comparison with other Sardinian populations. The oil was tested for cytotoxicity on three human tumor cell lines (MDA-MB 231, HCT116 and A375) by MTT assay showing a strong inhibitory activity on human malignant melanoma cells A375 (IC50 of 16 mu g/ml). In addition the oil was assessed for antioxidant activity by DPPH and ABTS assay.
2015
helichrysum; neryl acetate; rosifoliol; delta-cadinene; gamma-cadinene
01 Pubblicazione su rivista::01a Articolo in rivista
Chemical composition and biological activity of the essential oil from Helichrysum microphyllum Cambess. ssp. tyrrhenicum Bacch., Brullo e Giusso growing in La Maddalena Archipelago, Sardinia / Ornano, Luigi; Venditti, Alessandro; Cinzia, Sanna; Mauro, Ballero; Filippo, Maggi; Giulio, Lupidi; Massimo, Bramucci; Luana, Quassinti; Bianco, Armandodoriano. - In: JOURNAL OF OLEO SCIENCE. - ISSN 1347-3352. - STAMPA. - 64:1(2015), pp. 19-26. [10.5650/jos.ess14171]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/758637
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