Researchers believe that human muscle-derived cells are able to restore leak-point pressure to normal levels by differentiating into new muscle fibres that prevent anal sphincter muscle atrophy. Laboratory data are needed to identify exactly how these cells work to regenerate muscle. The objective of this study is to test whether stem cells can be employed to treat internal anal sphincter (IAS) injuries in humans; to this end, this work will use a two-step process to study: first, the effectiveness of the treatment in a sample of animals with artificial injuries to the IAS and then to verify the results in a population of selected humans affected by pathology
Human muscle-derived stem cells. Effectiveness in animal models of faecal incontinence. Research scheduling / Mongardini, Massimo; A., Lisi; Giofre', Manuel; M., Ledda; Grimaldi, Serena; Scarno', Marco; A., Trucchia; K. A., Kyriacou; Badiali, Danilo; Custureri, Filippo. - In: IL GIORNALE DI CHIRURGIA. - ISSN 0391-9005. - STAMPA. - 32:8/9(2011), pp. 357-360.
Human muscle-derived stem cells. Effectiveness in animal models of faecal incontinence. Research scheduling.
MONGARDINI, Massimo;GIOFRE', MANUEL;GRIMALDI, Serena;SCARNO', MARCO;BADIALI, Danilo;CUSTURERI, Filippo
2011
Abstract
Researchers believe that human muscle-derived cells are able to restore leak-point pressure to normal levels by differentiating into new muscle fibres that prevent anal sphincter muscle atrophy. Laboratory data are needed to identify exactly how these cells work to regenerate muscle. The objective of this study is to test whether stem cells can be employed to treat internal anal sphincter (IAS) injuries in humans; to this end, this work will use a two-step process to study: first, the effectiveness of the treatment in a sample of animals with artificial injuries to the IAS and then to verify the results in a population of selected humans affected by pathologyI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.