Smith-Magenis syndrome (SMS) is a microdeletion syndrome characterized by physical and neurobehavioural features. This report describes the case of a 27 year old female affected by SMS associated with a diagnosis, according to DSM-IV criteria, of Mood Disorder N.O.S. and Intermittent Explosive Disorder. To our knowledge, the association of SMS with mood shifts has never been reported. Considering the genetic alterations that characterizes the SMS, further investigations on the region of the chromosome 17p 11.2 could help produce more information on the role of melatonin in the genesis of mood disorder.
Mood disorder in a patient with Smith-Magenis syndrome: A case report / Bersani, Giuseppe; D., Russo; L., Limpido; D., Marconi. - In: NEUROENDOCRINOLOGY LETTERS. - ISSN 0172-780X. - STAMPA. - 28:1(2007), pp. 7-10.
Mood disorder in a patient with Smith-Magenis syndrome: A case report
BERSANI, Giuseppe;
2007
Abstract
Smith-Magenis syndrome (SMS) is a microdeletion syndrome characterized by physical and neurobehavioural features. This report describes the case of a 27 year old female affected by SMS associated with a diagnosis, according to DSM-IV criteria, of Mood Disorder N.O.S. and Intermittent Explosive Disorder. To our knowledge, the association of SMS with mood shifts has never been reported. Considering the genetic alterations that characterizes the SMS, further investigations on the region of the chromosome 17p 11.2 could help produce more information on the role of melatonin in the genesis of mood disorder.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
