We studied a new procedure of BOLD/fMRI acquisition in epilepsy. They use the benzodiazepine effect to achieve a more reliable baseline for statistical analysis. The method works only in the MR domain without EEG correlation. It compares the EPI images during interictal epileptic discharges and the images "inactivated" by benzodiazepine. The results in five out of eight patients show that this procedure in comparison with the EEG/tMRl method gives a net improvement of spatial definition of BOLD areas. These preliminary results seem to confirm the hypothesis that the better BOLD/fMRI procedure in epilepsy is to make use of physical features of MR that, unlike EEG, is not influenced by the distance of intercerebral sources and consequently allows a more complete and undistorted display of BOLD areas The results in five out of eight patients show that this procedure in comparison with the EEG/tMRl method gives a net improvement of spatial definition of BOLD areas. These preliminary results seem to confirm the hypothesis that the better BOLD/fMRI procedure in epilepsy is to make use of physical features of MR that, unlike EEG, is not influenced by the distance of intercerebral sources and consequently allows a more complete and undistorted display of BOLD areas
Hemodynamic response (BOLD/fMRI) in focal epilepsy with reference to benzodiazepine effect / Giovanni Battista, Ricci; Diego De, Carli; Colonnese, Claudio; Giancarlo Di, Gennaro; Pier Paolo, Quarato; Cantore, Giampaolo; Esposito, Vincenzo; Girolamo, Garreffa; Maraviglia, Bruno. - In: MAGNETIC RESONANCE IMAGING. - ISSN 0730-725X. - 22:10 SPEC. ISS.(2004), pp. 1487-1492. (Intervento presentato al convegno International School on Magnetic Resonance and Brain Function tenutosi a Erice, ITALY nel MAY 23-27, 2004) [10.1016/j.mri.2004.10.014].
Hemodynamic response (BOLD/fMRI) in focal epilepsy with reference to benzodiazepine effect
COLONNESE, Claudio;CANTORE, Giampaolo;ESPOSITO, Vincenzo;MARAVIGLIA, Bruno
2004
Abstract
We studied a new procedure of BOLD/fMRI acquisition in epilepsy. They use the benzodiazepine effect to achieve a more reliable baseline for statistical analysis. The method works only in the MR domain without EEG correlation. It compares the EPI images during interictal epileptic discharges and the images "inactivated" by benzodiazepine. The results in five out of eight patients show that this procedure in comparison with the EEG/tMRl method gives a net improvement of spatial definition of BOLD areas. These preliminary results seem to confirm the hypothesis that the better BOLD/fMRI procedure in epilepsy is to make use of physical features of MR that, unlike EEG, is not influenced by the distance of intercerebral sources and consequently allows a more complete and undistorted display of BOLD areas The results in five out of eight patients show that this procedure in comparison with the EEG/tMRl method gives a net improvement of spatial definition of BOLD areas. These preliminary results seem to confirm the hypothesis that the better BOLD/fMRI procedure in epilepsy is to make use of physical features of MR that, unlike EEG, is not influenced by the distance of intercerebral sources and consequently allows a more complete and undistorted display of BOLD areasI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
