Parkinson's disease, unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN), unlike bilateral stimulation, excludes ipsilateral confounding effects so that the contralateral effects of DBS on motor performance can be investigated alone. Because no kinematic study has yet investigated how unilateral STN-DBS affects the performance of a contralateral fast sequential motor act, we performed a kinematic analysis of the movement duration, switching time and spatial accuracy of a motor arm sequence in 10 parkinsonian patients. Patients were studied without dopaminergic therapy and when they were OFF and ON unilateral STN-DBS. We found that unilateral STN-DBS significantly improved movement time of a motor sequence and the switching time from one sequential step to the next, whereas accuracy deteriorated. We conclude that unilateral STN-DBS improves the performance of contralateral sequential arm movements in patients with Parkinson's disease.
Effects of unilateral subthalamic deep brain stimulation on contralateral arm sequential movements in Parkinson's disease / R., Agostino; L., Dinapoli; N., Modugno; E., Iezzi; P., Romanelli; Berardelli, Alfredo. - In: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. - ISSN 0022-3050. - 79:1(2008), pp. 76-78. [10.1136/jnnp.2007.122010]
Effects of unilateral subthalamic deep brain stimulation on contralateral arm sequential movements in Parkinson's disease
BERARDELLI, Alfredo
2008
Abstract
Parkinson's disease, unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN), unlike bilateral stimulation, excludes ipsilateral confounding effects so that the contralateral effects of DBS on motor performance can be investigated alone. Because no kinematic study has yet investigated how unilateral STN-DBS affects the performance of a contralateral fast sequential motor act, we performed a kinematic analysis of the movement duration, switching time and spatial accuracy of a motor arm sequence in 10 parkinsonian patients. Patients were studied without dopaminergic therapy and when they were OFF and ON unilateral STN-DBS. We found that unilateral STN-DBS significantly improved movement time of a motor sequence and the switching time from one sequential step to the next, whereas accuracy deteriorated. We conclude that unilateral STN-DBS improves the performance of contralateral sequential arm movements in patients with Parkinson's disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
