Methimazole (MMI) and propylthiouracil (PTU) are the main antithyroid drugs used for hyperthyroidism. They inhibit the synthesis of thyroid hormone at various levels and are used as the primary treatment for hyperthyroidism or as a preparation before radioiodine therapy or thyroidectomy. MMI is the drug of choice because of its widespread availability, longer half-life and small number of severe side effects. Drugs of second choice are potassium perchlorate, beta blockers, iodine, lithium carbonate and glucocorticoids. Rituximab, a monoclonal antibody directed against human CD20, was recently proposed as a biological therapy for cases of Graves' disease unresponsive to traditional drugs.
Medical Treatment of Hyperthyroidism: State of the Art / Fumarola, Angela; DI FIORE, Agnese; Dainelli, Michela; Grani, Giorgio; Calvanese, Anna. - In: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES. - ISSN 0947-7349. - STAMPA. - 118:10(2010), pp. 678-684. [10.1055/s-0030-1253420]
Medical Treatment of Hyperthyroidism: State of the Art
FUMAROLA, Angela;DI FIORE, AGNESE;DAINELLI, MICHELA;GRANI, Giorgio;CALVANESE, ANNA
2010
Abstract
Methimazole (MMI) and propylthiouracil (PTU) are the main antithyroid drugs used for hyperthyroidism. They inhibit the synthesis of thyroid hormone at various levels and are used as the primary treatment for hyperthyroidism or as a preparation before radioiodine therapy or thyroidectomy. MMI is the drug of choice because of its widespread availability, longer half-life and small number of severe side effects. Drugs of second choice are potassium perchlorate, beta blockers, iodine, lithium carbonate and glucocorticoids. Rituximab, a monoclonal antibody directed against human CD20, was recently proposed as a biological therapy for cases of Graves' disease unresponsive to traditional drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
